2004 Fiscal Year Final Research Report Summary
Programmed cell death of developing neurons following Bax overexpression
| Project/Area Number |
15590165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SATO Noboru Fukushima Medical University, School of Medicine, Department of Neuroanatomy & Embryology, Assistant Professor, 医学部, 講師 (00254756)
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| Project Period (FY) |
2003 – 2004
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| Keywords | chick / Bax / programmed cell death / retrovirus / motor neuron / dorsal root ganglion / retina |
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| Research Abstract |
Bax is a pro-apoptotic protein that is required for programmed cell death (PCD) of many neuronal populations. Here we show that, during an early period of retinal PCD and in naturally occurring sensory and motor neuron (MN) death in the spinal cord, Bar delivery results in enhanced death of these neural populations. In contrast, Bax overexpression fails to enhance an early phase of MN death that occurs in the cervical spinal cord, although overexpressed Bax appears to be activated in dying MNs. Bax overexpression does not also affect the survival of immature neurons prior to the PCD period. Taken together, these data provide the first in vivo evidence suggesting that Bax appears to act selectively as an executioner only in neurons undergoing PCD. Furthermore, although Bax appears to mediate the execution pathway for PCD, the effect of Bax overexpression on susceptibility to death differs between different neuronal populations.
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Research Products
(4 results)
