2004 Fiscal Year Final Research Report Summary
Dangerous QT prolongation can be assayed by using the chronic atrioventricular block dog
| Project/Area Number |
15590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SUGIYAMA Atsushi University of Yamanashi, Department of Research Interdisciplinary Graduate School of Medicine & Engineering, Associate professor, 大学院・医学工学総合研究部, 助教授 (60242632)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Long QT syndrome / Lathal arrhythmias / Drug / Safety Pharmacology / Complete AV block |
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| Research Abstract |
Torsadogenic potential of the QT interval prolonging drugs (sematilide, nifekalant, amiodarone, cisapride, terfenadine, sulpiride and sparfloxacin) was assessed using the chronic complete atrioventricular block dogs under the Holter ECG monitoring in conscious state (n=4-6 for each drug). Oral administration of <10 times higher of respective clinically relevant doses of the drugs induced torsades de pointer (TdP) except for amiodarone. These results indicate that the chronic atrioventricular block dog can become a useful strategy in estimating dangerous QT prolongation.
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Research Products
(25 results)
