2004 Fiscal Year Final Research Report Summary
Search for the molecular mechanism of action of a novel synthetic retinoid, acyclic retinoid
| Project/Area Number |
15590352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SUZUI Masumi University of the Ryukyus, Faculty of Medicine, Associate Professor, 医学部, 助教授 (30347158)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMI Naoki University of the Ryukyus, Faculty of Medicine, Professor, 医学部, 教授 (30166996)
MORIOKA Takamitsu University of the Ryukyus, Faculty of Medicine, Instructor, 医学部, 助手 (70253961)
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| Project Period (FY) |
2003 – 2004
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| Keywords | acyclic retinoid / p21^<CIP1> / RARβ / hepatoma / esophageal carcinoma / head and neck carcinoma / retinoid / chemoprevention |
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| Research Abstract |
Acyclic retinoid(ACR), a novel synthetic retinoid, can prevent the recurrence of hepatomas after surgical resection of primary tumors, but the molecular mechanisms by which ACR exerts anti-tumor effects are not known. In the present studies we found that growth inhibition of human hepatoma cells by ACR is associated with induction of p21^<CIP1> and inhibition of expression of cyclin D1. We also found that ACR activates retinoic acid receptor β and induces transcriptional activation of p21^<CIP1> in human hepatoma, and head and neck and esophageal squamous cell carcinoma cells. These novel effects of ACR suggest that this agent might be useful in the chemoprevention and therapy of various malignancies. Furthermore, the combination of ACR and OSI461, a potent derivative of exisulind, exerted synergistic inhibition of the growth of HepG2 cells. This result suggests that the combination of ACR and OSI461 might be an effective regimen for the chemoprevention and chemotherapy of human hepatoma and possibly other malignancies.
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Research Products
(28 results)
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[Journal Article] Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats.2005
Author(s)
Morioka, T., Suzui, M., Nabandith, V., Inamine, M., Aniya, Y., Nakayama, T., Ichiba, T., Yoshimi, N.
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Journal Title
Eur.J.Cancer Prev. (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Acyclic retinoid activates retinoic acid receptor β and induces transcriptional activation of p21^<CIP1> in HepG2 human hepatoma cells.2004
Author(s)
Suzui, M., Shimizu, M., Masuda, M., Lim, J.T.E., Yoshimi, N., Weinstein, I.B.
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Journal Title
Mol.Cancer Ther. 3
Pages: 309-316
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Synergistic effects of acyclic retinoid and OSI-461 on growth inhibition and gene expression in human hepatoma cells.2004
Author(s)
Shimizu, M., Suzui, M., Deguchi, A., Lim, J.T.E., Xao, D., Heyes, J.H., Papadopoulos, K.P., Weinstein, I.B.
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Journal Title
Clin.Cancer Res. 10
Pages: 6710-6721
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of acyclic retinoid on growth, cell cycle control, the EGFR signaling pathway, and gene expression in human squamous cell carcinoma cells.2004
Author(s)
Shimizu, M., Suzui, M., Lim, J.T.E., Weinstein, I.B.
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Journal Title
Clin.Cancer Res. 10
Pages: 1130-1140
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells.2004
Author(s)
Einbond, L.S., Shimizu, M.Xiao, D., Nuntanakorn, P., Lim, J.T., Suzui, M., Seter, C., Pertel.T., Kennelly, E.J., Kronenberg, F., Weinstein, I.B.
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Journal Title
Breast Cancer Res.Treat. 83
Pages: 221-231
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Inhibitory effects of crude α-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1,2-dimethylhydrazine in the rat.2004
Author(s)
Nabandith, V., Suzui, M., Morioka, T., Kaneshiro, T., Kinjo, T., Matsumoto, K., Akao, Y., Iinuma, M., Yoshimi, N.
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Journal Title
Asian Pac.J.Cancer Prev. 5
Pages: 427-432
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Histological and immunohistochemical observations of mucin-depleted foci(MDF) stained with alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride.2004
Author(s)
Yoshimi, N., Morioka, T., Kinjo, T., Inamine, M., Kaneshiro, T., Shimizu, T., Suzui, M., Yamada, Y., Mori, H.
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Journal Title
Cancer Sci. 95
Pages: 792-797
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The modifying effects of Peucedanum japonicum, an herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats.2004
Author(s)
Morioka, T., Suzui, M., Nabandith, V., Inamine, M., Aniya, Y., Nakayama, T., Ichiba, T., Mori, H., Yoshimi, N.
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Journal Title
Cancer Lett. 205
Pages: 133-141
Description
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[Journal Article] Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.2003
Author(s)
Su, T., Suzui, M., Wang, L., Lin, C-S., Xing, W-Q., Weinstein, I.B.
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Journal Title
Proc.Natl.Acad.Sci.USA. 100
Pages: 7824-7829
Description
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