2004 Fiscal Year Final Research Report Summary
Chlamydia pneumoniae infection and incident coronary heart disease
| Project/Area Number |
15590556
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Ibaraki Prefectural University of Health Sciences |
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Principal Investigator |
KOIKE Kazuko Ibaraki Prefectural University of Health Scienses, Center for Medical Sciences, School of Health Sciences, Professor, 保健医療学部, 教授 (60110508)
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| Co-Investigator(Kenkyū-buntansha) |
ISO Hiroyasu University of Tsukuba, Department of Public Health, Social Environmental Medicine, Graduate School of Comprehensive Human Sciences, Professor, 社会医学系, 教授 (50223053)
SATOH Shinichi The Osaka Medical Center for Health Science and Promotion, Chief of a section, 健康開発部, 部長
KOMADA Naomi KOMADA,Naomi, 助手 (10274979)
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| Project Period (FY) |
2003 – 2004
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| Keywords | Chlcanydiapnewnoniae infection / case-control study / coronary heart disease / cardiovascular disease / IMT of total carotid / IgA index values / risk factor |
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| Research Abstract |
Chlanzydia pneunnoniae infection and incident coronary heart disease
Chlanydia pnewnoniae is the third species of the genus Chlamydia and frequently causes community-acquired respiratory tract infections such as pharyngitis, bronchitis, and pneumonia. Seroprevalence of this organism is 50-70% in Japanese adults, and most people are thought to be infected several times in their lifetime. Recent seroepiderniologic studies suggest a relationship between chronic C. pneumoniae infection and incident heart disease. The chronic C. pnewnoniae infection maybe a risk factor for coronary heart disease. This presentation will give a review of the literature.
A case-control study concerning of risk factor of cardiovascular disease in Ibaraki lural population aged 50-70 men was investigated. Relationship between C. pnewnoniae infection and atherosclerosis was observed by seroepidemiologically 104 participantswith over 1.1 mm IMT of total carotid and 1.5 mm of internal carotid(case). Compared with controls (<1.1 mm IMT of total carotid and <1.5 mm of internal carotid, n =104), case with sclerosis of the carotid had higher IgA index values significantly. Repetitive and continuous infection of the C. pnewnoniae may increase the IgA index value. This result suggests that Ce pnewnoniae infection is a risk factor of athrosclerosis.
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