2004 Fiscal Year Final Research Report Summary
The roles of intestinal micro flora and it's metabolites, bile acids, and sulfated polysaccharides in the inflammatory bowel disease.
| Project/Area Number |
15590640
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
ARAKI Yoshio Shiga University of Medical Science, Department of Internal Medicine, Assistant Professor, 医学部, 助手 (00346032)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Keywords | bile acid / permeability / protein kinase C / sulfated polysaccharide |
|---|
| Research Abstract |
In the present study, we have made it clear that
1.bile acids increase the permeability of intestinal epithelium via the generation of reactive oxygen species, and the activation of intracellular signaling systems such as protein kinase C,
2.sulfated polysaccharides such as dextran sulfate sodium can be depolymerized in the gut lumen.
|
Research Products
(12 results)
