2005 Fiscal Year Final Research Report Summary
A study on the effect of nicotine on hepatic regulations
| Project/Area Number |
15590681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
YONEDA Masashi Dokkyo Medical University, School of Medicine, Department of Gastroenterology, Associate Professor, 医学部, 助教授 (30261407)
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| Project Period (FY) |
2003 – 2005
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| Keywords | nicotine / hepatic pathogenesis / neurotransmitter / hepatic circulation |
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| Research Abstract |
It is generally accepted that smoking affects human health mainly by studies on pulmonary and cardiovascular diseases. However, a little is known about an influence of smoking on hepatic physiological and pathophysiological regulations. An effect of nicotine on hepatic circulation was studied in rats. Rats were anesthetized with urethane and hepatic portal vein pressure and hepatic blood flow was measured by pressure transducer and laser Doppler flowmeter. Nicotine was administered intraportally and intracisternally after the stabilization of post-surgical state. Intraportal nicotine infusion induced dose-dependent increase portal pressure and hepatic blood flow. These changes of hepatic circulation were abolished by pretreatment of endothelin-1 antibody, and partially reversed by endothelin-A or endothelin-B pretreatment. Furthermore, combination pretreatment of endothelin-A and endothelin-B completely blocked the effects of intraportal nicotine infusion on portal pressure and hepatic blood flow. Intracisternal injection of nicotine also induced dose-dependent increase portal pressure and hepatic blood flow. These changes of hepatic circulation were abolished by hepatic sympatectomy or 6-OHDA pretreatment, but not by hepatic vagotomy.
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Research Products
(11 results)
