2005 Fiscal Year Final Research Report Summary
Identification of new lung cancer antigens and development of peptide vaccine
| Project/Area Number |
15590834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
YAMADA Akira Kurume University, Research center for Innovative Cancer Therapy, Professor, 先端癌治療研究センター, 教授 (50158177)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Cancer immunotherapy / Cancer antigens / Peptide vaccine / Cancer vaccine / Tumor Immunology / Translational Research / Cytotoxic T lymphocytes / Lung cancer |
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| Research Abstract |
We had cloned 6 cancer antigen genes and those derived 10 epitope peptides recognized by cytotoxic T-lymphocytes in an HLA-restricted manner were identified. Their expression is not restricted in the lung cancers but also found in other adenocarcinomas and squamous cell carcinomas with relatively high level of expression. Therefore we conducted clinical trials, as the translational research, of the personalized peptide vaccines for patients with various cancers including cancers of the lung, colon, stomach, pancreas, prostate, and malignant brain tumors in total 178 cases using these epitope peptides with previously identified peptides. Local inflammation at the injected sites was frequently observed, however, systemic adverse events have not been detected except for fever(grade 2 of CTCAE ver 3)in some cases. These results indicated the safety of the personalized peptide vaccines. Anti-tumor effects of the vaccines were confirmed in patients with glioblastoma maltiforme. In the case of hormone refractory prostate cancers, combination therapy with the vaccines and low dose estramustin phosphate expressed clinical effects. Since some of the vaccine peptides elicited immediate hypersensitivity-like skin reactions in the prevaccination skin tests, precise mechanisms of the reaction was investigated in animal models. The peptide-induced skin reaction was elicited by degranulation of the mast cells with antibody-independent mechanisms. However, this degranulation of the mast cells was not induced systemic anaphylaxis, because of the rapid degradation of the vaccine peptides in the plasma. This phenomenon was unelated to the anti-cancer effect of the peptide vaccines. We also demonstrated the synergic effect of the peptide vaccination and intratumor injection of OK432 on anti-tumor effect and its mechanism through the efficient recruitment of systemically induced CTLs to the tumor sites.
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Research Products
(66 results)
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[Journal Article] Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer.2005
Author(s)
Yamamoto K, Mine T, Katagiri K, Suzuki N, Kawaoka T, Ueno T, Matsueda S, Yamada A, Itoh K, Yamana H, Oka M.
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Journal Title
Oncol Rep. 13(5)
Pages: 875-883
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunological evaluation of vaccination of peptides derived from epithelial cancer-related antigens in two patients with hematological malignancy.2005
Author(s)
Takedatsu H, Yoshimoto K, Okamura T, Yakushij K, Imamura R, Hashiguchi M, Seki R, Obata Y, Harada M, Yamada A, Yamana H, Sata M, Itoh K.
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Journal Title
Int J Oncol. 26(6)
Pages: 1605-1612
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunologic evaluation of personalized peptide vaccination for patients with advanced malignant glioma.2005
Author(s)
Yajima N, Yamanaka R, Mine T, Tsuchiya N, Honma J, Sano M, Kuramoto T, Obata Y, Komatsu N, Arima Y, Yamada A, Shigemori M, Itoh K, Tanaka R.
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Journal Title
Clin Cancer Res. 11(16)
Pages: 5900-5911
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Vaccination with pre-designated or evidence-based peptides for patients with recurrent gynecologic cancers.2004
Author(s)
Tsuda N, Mochizuki K, Harada M, Sukehiro A, Kawano K, Yamada A, Ushijima K, Sugiyama T, Nishida T, Yamana H, Itoh K, Kamura T.
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Journal Title
J Immunother. 27(1)
Pages: 60-67
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] T cell receptor Vβ gene usage by T cells reactive with the tumor rejection antigen SART-1 in oral squamous cell carcinoma.2004
Author(s)
Kumamaru W, Nakamura S, Kadena T, Yamada A, Kawamura E, Sasaki M, Ohyama Y, Toyoshima T, Hayashida J, Itoh K, Shirasuna K.
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Journal Title
Int J Cancer. 108(5)
Pages: 686-695
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A phase I trial of CTL-precursor-oriented peptide vaccine for colorectal carcinoma patients.2004
Author(s)
Sato Y, Maeda Y, Sasatomi T, Takahashi M, Une Y, Kondo M, Shinohara T, Hida N, Katagiri K, Sato K, Yamada A, Yamana H, Itoh K, Todo S.
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Journal Title
Br J Cancer. 90(7)
Pages: 1334-1342
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides based on pre-existing peptide-specific cellular responses.2004
Author(s)
Mine T, Sato Y, Noguchi M, Sasatomi T, Gouhara R, Tsuda N, Tanaka S, Shomura H, Katagiri K, Rikimaru T, Shichijo S, Kamura T, Hashimoto T, Shirouze K, Yamada A, Todo S, Itoh K, Yamana H.
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Journal Title
Clin Cancer Res. 10(3)
Pages: 929-937
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunological evaluation of pre-designated vaccination of the peptides frequently vaccinated to cancer patients in an individualized peptide regimen.2004
Author(s)
Mochizuki K, Sato Y, Tsuda N, Shomura H, Sakamoto M, Matsuura K, Ushijima K, Maeda Y, Katagiri K, Yamada A, Todo S, Kamura T, Itoh K.
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Journal Title
Int J Oncol. 25(1)
Pages: 121-131
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Peptide vaccination for patients with melanoma and other types of cancers based on pre-existing peptide-specific cytotoxic T lymphocyte precursors in the periphery.2003
Author(s)
Tanaka S, Harada M, Mine T, Noguchi M, Gohara R, Azuma K, Tamura M, Yamada A, Morinaga A, Nishikori M, Katagiri K, Itoh K, Yamana H, Hashimoto T.
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Journal Title
J Immunother. 26(4)
Pages: 357-366
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunological evaluation of CTL precursor-oriented vaccines for advanced lung cancer patients.2003
Author(s)
Mine T, Gouhara R, Hida N, Imai N, Azuma K, Rikimaru T, Katagiri K, Nishikori M, Sukehiro A, Nakagawa M, Yamada A, Aizawa H, Shirouzu K, Itoh K, Yamana H.
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Journal Title
Cancer Sci. 94(6)
Pages: 548-556
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide.2003
Author(s)
Sato Y, Shomura H, Maeda Y, Mine T, Une Y, Akasaka Y, Kondo M, Takahashi S, Shinohara T, Katagiri K, Sato M, Okada S, Matsui K, Yamada A, Yamana H, Itoh K, Todo S.
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Journal Title
Cancer Sci. 94(9)
Pages: 802-808
Description
「研究成果報告書概要(欧文)」より
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