2004 Fiscal Year Final Research Report Summary
Preventive effects and its mechanisms of thermal therapy on atherosclerosis induced by life style-related diseases
| Project/Area Number |
15590950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kagoshima University |
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Principal Investigator |
BIRO Sadatoshi Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant Professor, 医学部・歯学部附属病院, 講師 (50244231)
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Masaaki Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Research Associate, 医学部・歯学部附属病院, 助手 (00347113)
TEI Chuwa Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (10163891)
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| Project Period (FY) |
2003 – 2004
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| Keywords | life style-related disease / vascular endothelial function / thermal therapy / atherosclerosis |
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| Research Abstract |
We have found that sauna therapy, a thermal therapy, improves impaired vascular endothelial function induced by life style-related diseases such as hypertension, hyperlipidemia, diabetes mellitus, smoking and obesity. We have also found that sauna therapy increases the expression of gene and protein of endothelial nitric oxide synthase in an experimental model using hamsters.
We, therefore, aimed to investigate whether sauna therapy inhibited progression of atherosclerosis through improvement of vascular endothelial function using apoE knockout mice.
Forty one degrees Centigrade sauna therapy for 15 minutes followed by 20 minutes at 34 degrees Centigrade raised the rectal temperature by about 1 degree Centigrade and remained elevated for about 20 minutes. We used 6-week apoE knockout mice in this study, because apparent atherosclerotic legions are observed at the base of aorta in 12- week apoE knockout mice.
Twenty 6-week apoE knockout mice were divided into 2 groups, sauna and control groups. In sauna group, they were treated with sauna therapy, once a day and 5 times per week. In control group, they were kept in an experimental sauna system switched off for 35 minutes. They were sacrificed after 10-week treatment and then aortas were resected. Microscopic measurement of aortic atherosclerotic area stained by Sudan III revealed that sauna therapy reduced atherosclerotic lesion area at the base of aorta (0.072 ± 0.03 mm2 vs. 0.22 ±0.14)
In conclusion, these results suggest that sauna therapy has a potential to inhibit the initiation and progression of atherosclerosis
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[Journal Article] Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters.2005
Author(s)
Ikeda Y, Biro S, Kamogawa Y, Yoshifuku S, Eto H, Orihara K, Yu B, Kihara T, Miyata M, Hamasaki S, Otsuji Y, Minagoe S, Tei C.
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Journal Title
Circ J. 69(6)
Pages: 722-729
Description
「研究成果報告書概要(欧文)」より
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