2005 Fiscal Year Final Research Report Summary
Voxel-based analysis of the diffusion tensor in psychiatric diseases
| Project/Area Number |
15591259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Osamu The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50302716)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Haruyasu The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (70359610)
KASAI Kiyoto The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (80322056)
AOKI Shigeki The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (80222470)
OHTOMO Kuni The University of Tokyo, Faculty of Medicine, Professor, 医学部附属病院, 教授 (80126010)
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| Project Period (FY) |
2003 – 2005
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| Keywords | magnetic resonance imaging / diffusion tensor / amyotrophic lateral sclerosis / normal agin / posttraumatic stress disorder / statistical parametric mapping / diffusion tensor tractography |
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| Research Abstract |
Recent functional neuroimaging work has suggested that interregional functional connectivity between the anterior cingulate cortex (ACC), other limbic, and prefrontal regions may be involved in the pathophysiology of posttraumatic stress disorder (PTSD). However, less attention has been paid to the white matter network. Voxel-based analysis enables an exploration of morphological or functional changes throughout the entire brain. Here we undertook the first application of this technology to diffusion tensor data in patients with PTSD. Participants were 9 victims of the Tokyo subway sarin attack with PTSD and 16 matched victims of the same traumatic event without PTSD. The voxel-based analysis showed a significant fractional anisotropy increase in the left anterior cingulum, subjacent to the left ACC gray matter where we previously found volume decrement, in PTSD subjects. Moreover, the severity was positively, but not significantly associated with the fractional anisotropy of the left anterior cingulum in the victims with PTSD, using the region of interest defined in the native space with the inverse normalization technique. The present study demonstrated further evidence of abnormalities of both the ACC, a structure which is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD.
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Research Products
(12 results)
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[Journal Article] Neuroanatomy in monozygotic twins with Asperger disorder discordant for comorbid depression.2005
Author(s)
Yamasue H, Ishijima M, Abe O, Sasaki T, Yamada H, Suga M, Rogers M, Minowa I, Someya R, Kurita H, Aoki S, Kato N, Kasai K.
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Journal Title
Neurology 65(3)
Pages: 491-492
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder : a study of victims of Tokyo subway sarin attack.2005
Author(s)
Araki T, Kasai K, Yamasue H, Kato N, Kudo N, Ohtani T, Nakagome K, Kirihara K, Yamada H, Abe O, Iwanami A.
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Journal Title
Neuroimage 25(1)
Pages: 43-50
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Amyotrophic lateral sclerosis : diffusion tensor tractography and voxel-based analysis.2004
Author(s)
Abe O, Yamada H, Masutani Y, Aoki S, Kunimatsu A, Yamasue H, Fukuda R, Kasai K, Hayashi N, Masumoto T, Mori H, Soma T, Ohtomo K.
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Journal Title
NMR Biomed 17(6)
Pages: 411-416
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia : an MRI parcellation study.2004
Author(s)
Yamasue H, Iwanami A, Hirayasu Y, Yamada H, Abe O, Kuroki N, Fukuda R, Tsujii K, Aoki S, Ohtomo K, Kato N, Kasai K.
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Journal Title
Psychiatry Res Neuroimaging 131(3)
Pages: 195-207
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Abnormal association between reduced magnetic mismatch field to speech sounds and smaller left planum temporale volume in schizophrenia.2004
Author(s)
Yamasue H, Yamada H, Yumoto M, Kamio S, Kudo N, Uetsuki M, Abe O, Fukuda R, Aoki S, Ohtomo K, Iwanami A, Kato N, Kasai K.
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Journal Title
Neuroimage 22(2)
Pages: 72O-727
Description
「研究成果報告書概要(欧文)」より
