2003 Fiscal Year Annual Research Report

優位側大脳半球の側頭葉下面における言語関連中枢の同定に関する研究

Research Project

Project/Area Number	15591520
Research Institution	Kyoto University
Principal Investigator	池田昭夫京都大学, 医学研究科, 講師 (90212761)
Co-Investigator(Kenkyū-buntansha)	福山秀直京都大学, 医学研究科, 教授 (90181297) 宮本享国立循環器病センター, 脳神経外科, 部長 (70239440) 大東祥孝京都大学, 人間・環境学研究科, 教授 (90169053) 三國信啓京都大学, 医学研究科, 助手 (60314217)
Keywords	言語中枢 / 側頭葉底部言語野 / 事象関連電位 / 慢性硬膜下電極 / 脳機能マッピング / Wada test
Research Abstract	平成15年度において、優位大脳半球の側頭葉下面における言語関連中枢の同定に関する研究を行い、次のような成果が得られた。 1)優位大脳半球同定に関する検査手法の確立言語優位半球の同定において、最も信頼性の高い検査であるWada testに従来使用されていたアモバルビタールの製造中止に伴い、アモバルビタールに替えて、本邦で初めて麻酔薬のプロポフォールを用いてWada testを実施し、プロポフォールがWada testにおいてアモバルビタールと同等の安全性と有効性を有することを証明し、実施手法を確立した。 2)優位半球側頭葉下面の脳機能マッピングによる言語機能の解明難治てんかん患者の術前検索の一環として、読み、書き、音声言語理解の要素を含む多様な言語課題を用いて側頭葉下面の皮質電気刺激による検索を行った結果、次のような知見を得た。(a)優位半球側頭葉下面は視覚言語処理過程と、聴覚言語処理過程の一部に関与している。(b)視覚言語処理過程に関しては、側頭葉下面内に漢字処理に関与する領域と仮名処理に関与する領域が別々に存在する。(c)漢字の認知処理過程と図形・絵の認知処理過程は一部共通要素を持つ。 3)優位半球側頭葉下面の事象関連電位による言語機能の解明漢字・かな文字単語の音読と物品の絵の呼称を中心とする課題を用いて側頭葉下面に留置した慢性硬膜下電極から事象関連電位を記録して解析を行い、現在、脳機能マッピングの結果との比較検討を進行中である。 4)術前術後での神経心理検査結果の検討皮質電気刺激結果の評価に基づいて、機能温存による難治側頭葉てんかん外科治療を行った症例について、術前の神経心理検査と術後1年にわたる追跡調査を実施し、術前術後の比較検討を実施中である。

Research Products
(19 results)

All Other

All Publications (19 results)

[Publications] Usui K: "Conversion of semantic information into phonological representation: a function in left posterior temporal area"Brain. 126. 632-641 (2003)
[Publications] Yoshida K: "Movement-related conical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)
[Publications] Hitomi T: "Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy"J Neurol Neurpsurg Psych. 74. 373-375 (2003)
[Publications] Yamamoto J: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizures (SII seizure)"J Neurol Neurpsurg Psych. 74. 367-369 (2003)
[Publications] Satow T: "Mirth and laughter arising from human temporal cortex"Clin Neurophysiol. 74. 1004-1005 (2003)
[Publications] Satow T: "Distinct cortical area for motor preparation and execution in human identified by Bereitschaftspotential recordng and ECoG-EMG coherence"Clin Neurophysiol. 114. 1259-1264 (2003)
[Publications] Matsumoto R: "Functional subdivisions of human premotor cortex: epicortical recoroding in visiomotor task"Clin Neurophysiol. 114. 1102-1115 (2003)
[Publications] Yazawa S: "Painful sensory seizure arising from the primary somstosensory cortex"Int Med. 42. 875-879 (2003)
[Publications] Matsuhashi M: "Fmultimodal sensory processing in human temporo-parietal junction- epicortical recording of sensory evoked responses-"Clin Neurophysiol. (in press). (2004)
[Publications] Kunieda T: "Role of the lateral non-primary motor area in humans as revealed by Bereitschaftspotential"Exp Brain Res. (in press). (2004)
[Publications] Yamamoto J: "Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials"Brain. (in press). (2004)
[Publications] Satow T: "Role of primary sensorimotor cortex and supplementary motor area in volitional swallowing : a movement-related cortical potential Study."American Journal of Physiology-Gastrointestinal and Liver Physiology. (in press). (2004)
[Publications] Miyamoto S: "Combined Subtemporal and transventricular/ trans-choroidal fissure Approach To Medial Temporal Lesions"Neurosurgery. (in press). (2004)
[Publications] Kinoshita M: "Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes"Epilepsia. (in press). (2004)
[Publications] Ikeda A: "Diffuse encephalopathies. In : Ebersole JS and Pedley TA (eds): Current practice of clinical electroencephalography. 3rd edition. (分担執筆)"Lippincott Williams & Wilkins, Philadelphia. 30 (2003)
[Publications] Ikeda A: "Intracranial recording of Bereitschaftspotentials in patients with epilepsy. The Bereitschaftspotentials : movement-related cortical potentials (分担執筆)"Kluwer Academic/Plenum. 15 (2003)
[Publications] Ikeda A.: "Electrocorticography in motor control and movement disorders Handbook of Clinical neurphysiology : Movemene Disorders (分担執筆)"Elsevier. 14 (2004)
[Publications] Ikeda A.: "Special EEG recording with ictal pattern. Handbook of Clinical Neurphysiology : epilepsy (分担執筆)"Elsevier. (2004)
[Publications] Ikeda A: "Event-related evoked potentials to delinate eloquent cortex. Handbook of Clinical neurphysiology (分担執筆)"Elsevier. (2004)

2003 Fiscal Year Annual Research Report

優位側大脳半球の側頭葉下面における言語関連中枢の同定に関する研究

Principal Investigator

池田 昭夫 京都大学, 医学研究科, 講師 (90212761)

Research Products

[Publications] Usui K: "Conversion of semantic information into phonological representation: a function in left posterior temporal area"Brain. 126. 632-641 (2003)

[Publications] Yoshida K: "Movement-related conical potentials before jaw excursions in oromandibular dystonia"Mov Disord. 18. 94-100 (2003)

[Publications] Hitomi T: "Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy"J Neurol Neurpsurg Psych. 74. 373-375 (2003)

[Publications] Yamamoto J: "Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizures (SII seizure)"J Neurol Neurpsurg Psych. 74. 367-369 (2003)

[Publications] Satow T: "Mirth and laughter arising from human temporal cortex"Clin Neurophysiol. 74. 1004-1005 (2003)

[Publications] Satow T: "Distinct cortical area for motor preparation and execution in human identified by Bereitschaftspotential recordng and ECoG-EMG coherence"Clin Neurophysiol. 114. 1259-1264 (2003)

[Publications] Matsumoto R: "Functional subdivisions of human premotor cortex: epicortical recoroding in visiomotor task"Clin Neurophysiol. 114. 1102-1115 (2003)

[Publications] Yazawa S: "Painful sensory seizure arising from the primary somstosensory cortex"Int Med. 42. 875-879 (2003)

[Publications] Matsuhashi M: "Fmultimodal sensory processing in human temporo-parietal junction- epicortical recording of sensory evoked responses-"Clin Neurophysiol. (in press). (2004)

[Publications] Kunieda T: "Role of the lateral non-primary motor area in humans as revealed by Bereitschaftspotential"Exp Brain Res. (in press). (2004)

[Publications] Yamamoto J: "Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials"Brain. (in press). (2004)

[Publications] Satow T: "Role of primary sensorimotor cortex and supplementary motor area in volitional swallowing : a movement-related cortical potential Study."American Journal of Physiology-Gastrointestinal and Liver Physiology. (in press). (2004)

[Publications] Miyamoto S: "Combined Subtemporal and transventricular/ trans-choroidal fissure Approach To Medial Temporal Lesions"Neurosurgery. (in press). (2004)

[Publications] Kinoshita M: "Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes"Epilepsia. (in press). (2004)

[Publications] Ikeda A: "Diffuse encephalopathies. In : Ebersole JS and Pedley TA (eds): Current practice of clinical electroencephalography. 3rd edition. (分担執筆)"Lippincott Williams & Wilkins, Philadelphia. 30 (2003)

[Publications] Ikeda A: "Intracranial recording of Bereitschaftspotentials in patients with epilepsy. The Bereitschaftspotentials : movement-related cortical potentials (分担執筆)"Kluwer Academic/Plenum. 15 (2003)

[Publications] Ikeda A.: "Electrocorticography in motor control and movement disorders Handbook of Clinical neurphysiology : Movemene Disorders (分担執筆)"Elsevier. 14 (2004)

[Publications] Ikeda A.: "Special EEG recording with ictal pattern. Handbook of Clinical Neurphysiology : epilepsy (分担執筆)"Elsevier. (2004)

[Publications] Ikeda A: "Event-related evoked potentials to delinate eloquent cortex. Handbook of Clinical neurphysiology (分担執筆)"Elsevier. (2004)

池田昭夫京都大学, 医学研究科, 講師 (90212761)