Identification of language-related area in the basal temporal cortex in the dominant hemisphere

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 15591520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: KYOTO UNIVERSITY
• Principal Investigator: IKEDA Akio Kyoto University, Graduate School of Medicine, Lecturer, 医学研究科, 講師 (90212761)
• Co-Investigator(Kenkyū-buntansha): OHIGASHI Yoshitaka Kyoto University, Graduate School of Human and Environmental Studies, Professor, 人間・環境学研究科, 教授 (90169053) ; MIYAMOTO Susumu National Cardiovascular Center, Head of Department of Neurosurgery, 脳神経外科, 部長 (70239440) ; FUKUYAMA Hidenao Kyoto University, Graduate School of Medicine, Professor, 医学研究科, 教授 (90181297) ; MIKUNI Nobuhiro Kyoto University, Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (60314217)
• Project Period (FY): 2003 – 2004
• Keywords: Language area / Basal temporal language area / Event-related potentials / Chronic implantation of subdural electrode / functional cortical mapping / Wada test

Research Abstract

We investigated the function and the localization of the left basal temporal language area (LBTA) in patients with intractable left mesial temporal lobe epilepsy as follows.
(1) Functions of LBTA by means of electric cortical stimulation
Reading, writing auditory comprehension were investigated while LBTA was stimulated. It was concluded that (a) LBTA was involved in visual- and auditory-language processing, at least independently, each dealing with morphological/semantic and phonological information, respectively, (b) kanji words and kana non-words were independently processed in the LBRA, and (c) cognitive processing of kanji words and object/picture partly shared the same process in the LBTA.
(2) Event-related potential study in the LBTA for the language function
Event-related potentials were recorded from the patients with intractable left mesial temporal lobe epilepsy by means of subdural electrodes implanted on the left basal temporal cortex and depth electrodes within the hippocampu s, where the patients were requested to read visually presented kanji/ kana words and to name the presented picture/objects silently. As the result, N200 potentials were recognized in response to the silent reading at or very close to LBTA.
(3) Neuropsychological analysis in association with left selective hippocampectomy
Neuropsychological analysis such as Wechsler Memory Scale-Revised was investigated in patients with intractable left mesial temporal lobe epilepsy after left selective hippocampectomy. After surgery, verbal memory score became higher as compared with before surgery. It could suggest that LBTA could play the significant role in verbal memory function, probably as combined with hippocampus.
(4)Clinical methods define the language dominancy in the cerebral hemispheres
Wada test with amobarbital is one of the most reliable methods to define the language and memory dominancies in the cerebral hemispheres. We demonstrated that clinically propofol was as useful as amobarbital in Wada test for patients before epilepsy surgery and lesion surgery.

Research Products

• [Journal Article] Dominance of ipsilateral coorticospinal pathway in congenital mirror movements. (2005)
  • Author(s): Teki Y, Mima T, Oga T, Ikeda A, et al.
  • Journal Title: J Neurol Neurpsurg Psych 76 Pages: 276-279
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effects of trans-sylvian approach on basal forebrain projection fibers : verbal memory decline in selective amygdalohippocampectomy.mu (2005)
  • Author(s): Ikeda A, Miyamoto S, Tomimoto H, et al.
  • Journal Title: Epilepsia 46 Pages: 334
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Frontal non-convulstive status epilepticus manifesting somatic hallucination. (2005)
  • Author(s): Takaya S, Matsumoto R, Namiki C, et al.
  • Journal Title: J Neurol Sci (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Possible anticipation in BAFME : examined three generations in a Japanese family. (2005)
  • Author(s): Ikeda A, Kurihara S, Shibasaki H, et al.
  • Journal Title: Mov Disord (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Processing of Japanese morphogram and syllabogram in the left basal temporal area : electrical cortical stimulation studies. (2005)
  • Author(s): Usui K, Ikeda A, Takayama M, et al.
  • Journal Title: Cog Brain Res (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy. (2005)
  • Author(s): Kinoshita M, Ikeda A, Matsuhashi M, et al.
  • Journal Title: Clin Neurophysiol (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy. (2005)
  • Author(s): Nakamura M, Chen Q, Sugi T, Ikeda A, et al.
  • Journal Title: Med Eng Physics 27 Pages: 93-100
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp. (2005)
  • Author(s): Murase N, Rothwell JC, Kaji R, Urushihara R, Nakamura K, Murayama N, Igasaki T, Sakata-Igasaki M, Mima T, Ikeda A, Shibasaki H
  • Journal Title: Brain 128 Pages: 104-115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dominance of ipsilateral coorticospinal pathway in congenital mirror movements. (2005)
  • Author(s): Ueki Y, Mima T, Oga T, Ikeda A, Hitomi T, Fukuyama H, Nagamine T, Shibasaki H
  • Journal Title: J Neurol Neurpsurg Psych 76 Pages: 276-279
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of trans-sylvian approach on basal forebrain projection fibers : verbal memory decline in selective amygdalohippocampectomy. (2005)
  • Author(s): Ikeda A, Miyamoto S, Tomimoto H, Mikuni N, Fukuyama N, Hashimoto N
  • Journal Title: Epilepsia 46 Pages: 334
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frontal non-convulstive status epilepticus manifesting somatic hallucination. (2005)
  • Author(s): Takaya S, Matsumoto R, Namiki C, Kiyosu H, Isono O, Hashikawa K, Ikeda A, Fukuyama H
  • Journal Title: J Neurol Sci (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible anticipation in BAFME : examined three generations in a Japanese family. (2005)
  • Author(s): Ikeda A, Kurihara S, Shibasaki H
  • Journal Title: Mov Disord (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Processing of Japanese morphogram and syllabogram in the left basal temporal area : electrical cortical stimulation studies. (2005)
  • Author(s): Usui K, Ikeda A, Takayama M, Matsuhashi M, Satow T, Begum T, Kinoshita M, Miyamoto S, Hashimoto N, Nagamine T, Fukuyama H, Shibasaki H
  • Journal Title: Cog Brain Res(available in e-journal) (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electric cortical stimulation suppresses epileptic and background activities in neocortical epilepsy and mesial temporal lobe epilepsy. (2005)
  • Author(s): Kinoshita M, Ikeda A, Matsuhashi M, Matsumoto R, Hitomi T, Begum T, Usui K, Takayama M, Mikuni N, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: Clin Neurophysiol (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Technical quality evaluation of EEG recording based on electtroencephalographers' knowledge. (2005)
  • Author(s): Nakamura M, Chen Q, Sugi T, Ikeda A, Shibasaki H
  • Journal Title: Med Eng Physics 27 Pages: 93-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hypersomnia caused by isolated angitis of the CNS. (2005)
  • Author(s): Nakaji K, Ikeda A, Oka Y, Tomimoto H, Shimohama S, Kanbayashi T, Shibasaki H
  • Journal Title: Int Med (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Multimodal sensory processing in human temporo-parietal junction-epicortical recording of sensory evoked responses-. (2004)
  • Author(s): Matsuhashi M, Ikeda A, et al.
  • Journal Title: Clin Neurophysiol 115 Pages: 1145-1160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of the lateral non-primary motor area in humans as revealed by Bereitschaftspotential (2004)
  • Author(s): Kunieda T, Ikeda A, et al.
  • Journal Title: Exp Brain Res 156 Pages: 135-148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials (2004)
  • Author(s): Yamamoto J, Ikeda A, Satow, et al.
  • Journal Title: Brain 127 Pages: 873-887
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Role of primary sensorimotor cortex and supplementary motor area in volitional swallowing : a movement-related cortical potential study. (2004)
  • Author(s): Satow T, Ikeda A, Yamamoto J, et al.
  • Journal Title: American Journal of Physiology-Gastrointestinal and Liver Physiology 287 Pages: G459-G470
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Combined subtemporal and transventricular/ trans-choroidal fissure approach to medial temporal lesions. (2004)
  • Author(s): Miyamoto S, Kataoka H, Ikeda A, et al.
  • Journal Title: Neurosurgery 54 Pages: 1162-1169
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes. (2004)
  • Author(s): Kinoshita M, Ikeda A, Matsumoto R, et al.
  • Journal Title: Epilepsia 45 Pages: 787-791
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Intracarotid propofol test for speech and memory dominance in man. (2004)
  • Author(s): Takayama M, Miyamoto S, Ikeda A, et al.
  • Journal Title: Neurology 63 Pages: 511-515
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Subregions of human MT complex revealed by comparative MEG and direct electrocorticographic recordings. (2004)
  • Author(s): Matsumoto R, Ikeda A, Nagamine T, et al.
  • Journal Title: Clin Neurophysiol 115 Pages: 2056-2065
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Surgical treatment of seizures from the perisylvian area by perinatal insult : a case report of ictal hypersalivation. (2004)
  • Author(s): Satow T, Ikeda A, Hayashi N, et al.
  • Journal Title: Acta Neurochirurgica 146 Pages: 1021-1026
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Subthreshold low-frequency repetitive transcranial magnetic stimulation over the premotor cortex modulates writer's cramp. (2004)
  • Author(s): Murase N, Rothwell JC, Kaji R, et al.
  • Journal Title: Brain 128 Pages: 104-115
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Propagation of tonic posturing in supplementary motor area (SMA) seizures. (2004)
  • Author(s): Ohara S, Ikeda A, Kunieda T, et al.
  • Journal Title: Epilepsy Research 62 Pages: 179-187
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Fmultimodal sensory processing in human temporo-parietal junction-epicortical recording of sensory evoked responses-. (2004)
  • Author(s): Matsuhashi M, Ikeda A, Ohara S, Matsumoto R, Yamamoto J, Takayama M, Satow T, Begum T, Usui K, Nagamine T, Mikuni N, Takahashi J, Miyamoto S, Fukuyama H, Shibasaki H
  • Journal Title: Clin Neurophysiol 115 Pages: 1145-1160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of the lateral non-primary motor area in humans as revealed by Bereitschaftspotential. (2004)
  • Author(s): Kunieda T, Ikeda A, Ohara S, Matsumoto R, Taki W, Hashimoto N, Baba K, Inoue Y, Mihara T, Yagi K, Shibasaki H
  • Journal Title: Exp Brain Res 156 Pages: 135-148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human eye fields in the frontal lobe as studied by epicortical recording of movement-related cortical potentials. (2004)
  • Author(s): Yamamoto J, Ikeda A, Satow, Matsuhashi M, Baba K, Yamane F, Miyamoto S, Mihara T, Hori T Taki W, Hashimoto N, Shibasaki H
  • Journal Title: Brain 127 Pages: 873-887
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of primary sensorimotor cortex and supplementary motor area in volitional swallowing : a movement-related cortical potential study. (2004)
  • Author(s): Satow T, Ikeda A, Yamamoto J, Begum T, Thuy DHD, Matsuhashi M, Mima M, Nagamine T, Baba K, Mihara T, Inoue Y, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: American Journal of Physiology-Gastrointestinal and Liver Physiology 287 Pages: G459-G470
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Combined subtemporal and transventricular/transchoroidal fissure approach to medial temporal lesions. (2004)
  • Author(s): Miyamoto S, Kataoka H, Ikeda A, Takahashi J, Mikuni N, Usui K, Takayama M, Satow T, Hashimoto N
  • Journal Title: Neurosurgery 54 Pages: 1162-1169
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes. (2004)
  • Author(s): Kinoshita M, Ikeda A, Matsumoto R, Begum T, Usui K, Yamamoto J, Matsuhashi M, Takayama M, Mikuni N, Takahashi J, Miyamoto S, Shibasaki H
  • Journal Title: Epilepsia 45 Pages: 787-791
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intracarotid propofol test for speech and memory dominance in man. (2004)
  • Author(s): Takayama M, Miyamoto S, Ikeda A, Mikuni N, Takahashi J, Usui K, Satow T, Yamamoto J, Matsuhashi M, Matsumoto R, Nagamine T, Shibasaki H, Hashimoto N
  • Journal Title: Neurology 63 Pages: 511-515
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Subregions of human MT complex revealed by comparative MEG and direct electrocorticographic recordings. (2004)
  • Author(s): Matsumoto R, Ikeda A, Nagamine T, Matsuhashi M, Ohara S, Yamamoto J, Toma K, Mikuni N, Takahashi J, Miyamoto S, Fukuyama H, Shibasaki H
  • Journal Title: Clin Neurophysiol 115 Pages: 2056-2065
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Surgical treatment of seizures from the perisylvian area by perinatal insult : a case report of ictal hypersalivation. (2004)
  • Author(s): Satow T, Ikeda A, Hayashi N, Yamamoto J, Takayama M, Matsuhashi M, Mikuni N, Takahashi J, Shibasaki H, Miyamoto S, Hashimoto N
  • Journal Title: Acta Neurochirurgica 146 Pages: 1021-1026
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex. (2004)
  • Author(s): Shibasaki H, Hitomi H, Mezaki T, Kihara T, Tomimoto H, Ikeda A, Shimohama S, Oka N
  • Journal Title: J Neurol 251 Pages: 1340-1344
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Propagation of tonic posturing in supplementary motor area (SMA) seizures. (2004)
  • Author(s): Ohara S, Ikeda A, Kunieda T, Yazawa S, Tak J, Nagamine T, TakiW, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: Epilepsy Res 62 Pages: 179-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Conversion of semantic information into phonological representation : a function in left posterior temporal area. (2003)
  • Author(s): Usui K, Ikeda A, Takayama M, Matsuhashi M, Yamamoto J-I, Satoh T, Begum T, Kinoshita M, Takahashi JB, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: Brain 126 Pages: 632-641
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Movement-related cortical potentials before jaw excursions in oromandibular dystonia. (2003)
  • Author(s): Yoshida K, Kaji R, Kohara N, Murase N, Ikeda A, Shibasaki H, Iizuka T
  • Journal Title: Mov Disord 18 Pages: 94-100
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy. (2003)
  • Author(s): Hitomi T, Mezaki T, Tsujii T, Kinoshita M, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H
  • Journal Title: J Neurol Neurpsurg Psych 74 Pages: 373-375
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Seizures arising from the inferior parietal lobule can show ictal semiology of the second sensory seizures (SII seizure). (2003)
  • Author(s): Yamamoto J, Ikeda A, Matsuhashi M, Satow T, Takayama M, Ohara S, Matsumoto R, Mikuni M, Takahashi JB, Miyamoto S, Taki W, Hashimoto N, Shibasaki H
  • Journal Title: J Neurol Neurpsurg Psych 74 Pages: 367-369
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mirth and laughter arising from human temporal cortex. (2003)
  • Author(s): Satow T, Ikeda A, Usui K, Matsuhashi M, Yamamoto J, Begum T, Mikuni M, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: J Neurol Neurpsurg Psych 74 Pages: 1004-1005
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct cortical area for motor preparation and execution in human identified by Bereitschaftspotential recording and ECoG-EMG coherence. (2003)
  • Author(s): Satow T, Matsuhashi M, Ikeda A, Yamamoto J, Takayama M, Begum T, Mima T, Nagamine T, Mikuni N, Miyamoto S, Hashimoto N, Shibasaki H
  • Journal Title: Clin Neurophysiol 114 Pages: 1259-1264
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional subdivisions of human premotor cortex : epicortical recording in visiomotor task. (2003)
  • Author(s): Matsumoto R, Ikeda A, Ohara S, Matsuhashi M, Baba K, Yamane F, Hori T, Mihara T, Nagamine T, Shibasaki H
  • Journal Title: Clin Neurophysiol 114 Pages: 1102-1115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Painful sensory seizure arising from the primary somstosensory cortex. (2003)
  • Author(s): Yazawa S, Ikeda A, Sawamoto N, Terada K, Fukuyama H, Tanaka M, Shibasaki H
  • Journal Title: Int Med 42 Pages: 875-879
  • Description: 「研究成果報告書概要(欧文)」より