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2004 Fiscal Year Final Research Report Summary

Fetal programming on adult hypertension in pregnant rats under severe nutrition.

Research Project

Project/Area Number 15591770
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionFukushima Medical University

Principal Investigator

OKAWA Toshiaki  Fukushima Medical University, OB/Gti., Lecturer, 産婦人科, 講師 (00254011)

Project Period (FY) 2003 – 2004
KeywordsFetus / program / hypertension / nutrition / nitric oxide / pregnancy / rat
Research Abstract

There was no difference in litter size between restricted (R) and Control (C) groups (R group (9.3±0.7, C group (10.6±0.7)). Body weight was significantly reduced in R offspring compared to C in both male and female offspring at day 1(R male ; 4.2±0.1g vs C male ; 5.2±0.1g, R female ; 4.1±0.1g vs C female ; 5.2±0.1g). Female body weight of R was no different to catch up from female offspring of C by only 2 weeks. (R female ; 17.5±1.0g vs C female ; 17.9±0.4g). However, male body weight of R was no different from male offspring of C by week 8 (R male ; 175.5±4.3g vs C male ; 174.0±2.1g. In 8 week offspring, systolic, diastolic and mean blood pressures (BP) were all significantly elevated in female rats of R compared with C. However, in male offspring, only systolic BP of R was significantly increased compared with C. Heart rate is not difference in C and R offspring. In 16 week offspring, systolic, diastolic and mean BP were all more elevated in female rats of R compared with C. In male offspring, systolic and mean BP of R was significantly increased compared with C. Heart rate was not difference in C and R male offspring. NE concentration-dependently stimulated tension of aortic rings from in C and R offspring, which was not significantly. Maximal contractions to NE were significantly stimulated by L-NAME in C, but not R offspring. Valsartan significantly inhibited aortic contractions by NE in R, but not C offspring. Conclusions : Severe under nutrition during late gestation in rats leads to transient growth restriction in the pups, induces hypertension in male and female offspring in adulthood. Fetal origin of adult hypertension might be gender-dependent, especially female. Fetal origin of adult hypertension might be vascular endothelial dysfunction.

  • Research Products

    (11 results)

All 2004 2003

All Journal Article (11 results)

  • [Journal Article] The rats of endothelin-1 and nitric oxide in tlwbks2004

    • Author(s)
      Okawa T. et al.
    • Journal Title

      Fental Diag Ther 19

      Pages: 94

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 低栄養妊娠ラット新生仔の高血圧発症とその機序2003

    • Author(s)
      橋本敏, 大川敏明 他
    • Journal Title

      医学の歩み 207

      Pages: 157-158

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fetal programming on adult hypertension inprognat-2003

    • Author(s)
      Hashimoto, S., Okawa, T.
    • Journal Title

      J.Perinatol Med. 31

      Pages: 237

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fetal programming of hyprtencsa alue to vascanber end2003

    • Author(s)
      Hashimoto S., Okawa T.
    • Journal Title

      J.Perinatal Med 31

      Pages: 238

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Severe dietary restriction in preprat rats causes genola2003

    • Author(s)
      Hashimoto S., Okawa T.
    • Journal Title

      Pediatric Res 53

      Pages: 31A

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Severe dietary restriction in preprat rats casse hyprtensin -2003

    • Author(s)
      Okawa T. et al.
    • Journal Title

      Pediatric Res 53

      Pages: 31A

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fetal programming on adult hypertension in pregnant rats under severe nutrition.2003

    • Author(s)
      Hashimoto S, Okawa T, Takahashi H, Anbe H, Yanagida K, Sato A
    • Journal Title

      Igaku no ayumi (in Japanese) 207

      Pages: 157-158

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fetal programming on adult hypertension in pregnant rats under severe nutrition.2003

    • Author(s)
      Hashimoto S, Okawa T, Anbe H, Takahashi H, Fujimori K, Sato A
    • Journal Title

      J Perinatal Med 31(Suppl)

      Pages: 237

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fetal programing of hypertension due to vascular endothelial dysfunction in rat offspring.2003

    • Author(s)
      Hashimoto S, Okawa T, Anbe H, Takahashi H, Fujimori K, Sato A
    • Journal Title

      J Perinatal Med 31(Suppl)

      Pages: 238

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Severe dietary restriction in pregnant rats causes gender-related hypertension in offspring.2003

    • Author(s)
      Hashimoto S, Okawa T, Anbe H, Takahashi H, et al.
    • Journal Title

      Pediatric Res 53(6)

      Pages: 31A

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Severe dietary restriction in pregnant rats causes hypertension due to vascular dysfunction in offspring.2003

    • Author(s)
      Okawa T, Hashimoto S, Anbe H, Takahashi H, et al.
    • Journal Title

      Pediatric Res 53(6)

      Pages: 31A

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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