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2004 Fiscal Year Final Research Report Summary

Involvement of inflammation-related enzymes and PPARs in tongue carcinogenesis and inhibition of tongue carcinogenesis by their inhibition

Research Project

Project/Area Number 15592007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKANAZAWA MEDICAL UNIVERSITY

Principal Investigator

TANAKA Takuji  Kanazawa Medical University, Department of Oncologic Pathology, Professor, 医学部, 教授 (40126743)

Co-Investigator(Kenkyū-buntansha) KOHNO Hiroyuki  Kanazawa Medical University, Department of Oncologic Pathology, Associate Professor, 医学部, 助教授 (20221236)
Project Period (FY) 2003 – 2004
Keywordsrat / tongue carcinogenesis / IL-α / IL-β / mast cell / angiogenesis
Research Abstract

We conducted an in vivo experiment to clarify certain relation of inflammation and tongue carcinogenesis. Male F344 rats (4 weeks of age) were given 4-nitroquinoline 1-oxide (4-NQO, 20 ppm) in their drinking water for 8 weeks, and then they were untreated up to 32 experimental weeks. At sacrifice, tongues of all animals were removed and histopathologically examined. Also, IL-α, IL-β, and the densities of mast cells and microvessels were assayed in the stroma of various tongue lesions including non-lesional areas, hyperplastic lesions, dysplastic lesions, and squamous cell carcinomas. The measurements are as follows : IL-α (pg/mg), 7.8±1.5 in the non-lesional areas 13.8±4.6 the hyperplastic lesions, 37.8±7.9 in the dysplastic lesion, 45.1±7.7 in the squamous cell carcinomas ; IL-β (pg/mg), 0.81±0.18 in the non-lesional areas 1.43±0.48 in the hyperplastic lesions, 3.92±0.59 in the dysplastic lesions. 4.62±0.61 in the squamous cell carcinomas ; density of the tryptase-positive mast cell ( … More /mm^2), 6.5±1.6 in the non-lesional areas, 9.9±2.0 in the hyperplastic lesions, 18.4±2.0 in the dysplastic lesions, 28.4±5.2 in the squamous cell carcinomas ; density of the CD31-positive neogenesis microvessel (/mm^2), 18.0±1.8 in the non-lesional areas, 17.8±4.6 in the hyperplastic lesions, 28.4±5.8 in the dysplastic lesions, 51.8±7.2 in the squamous cell carcinomas. All the values significantly increased with development of tongue carcinogenesis process (P <0.05). These results may indicate that inflammation was associated with development of tongue carcinogenesis, particularly malignant conversion. In addition, the correlation of the increase in the density of the mast cell and angiogenesis were suggested. In particular, an increase in mast cell density was observed in the front of cancer invasion.
Our findings may suggest that inflammatory mast cell mobilized in the preneoplastic lesions and front of the cancer invasion reorganize their stroma in order to promote angiogenesis. We are now analyzing relationship between PPARs' expression and angiogenetic using samples obtained in this experiment in order to establish a novel strategy of chemoprevention against tongue cancer development. Less

  • Research Products

    (56 results)

All 2005 2004

All Journal Article (56 results)

  • [Journal Article] Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess β-catenin gene mutations and increases immunoreactivity for β-catenin, cyclooxygenase-2, and inducible nitric oxide synthase2005

    • Author(s)
      akuji Tanaka, et al.
    • Journal Title

      Carcinogenesis 26

      Pages: 229-238

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice : attenuation of pro-inflammatory gene expression2005

    • Author(s)
      Ki Han Kwon, et al.
    • Journal Title

      Biochem.Pharmacol. 69

      Pages: 395-406

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effect of α-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine(PhIP)-induced mammary carcinogenesis in rats2005

    • Author(s)
      Shigeyuki Sugie, et al.
    • Journal Title

      Int.J.Cancer 110(in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats2005

    • Author(s)
      koujiro Yoshida, et al.
    • Journal Title

      Cancer Lett. 215(in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane2005

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Histol.Histopathol. 19(in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] β-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate2005

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. 96(in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prevention o rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-α-expressing oval-like cells and activated hepatic stellate cells2005

    • Author(s)
      Tetsuro Sano, et al.
    • Journal Title

      Carcinogenesis 51(in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess β-catenin gene mutations and increases immunoreactivity for β-catenin, cyclooxygenase-2, and inducible nitric oxide synthase.2005

    • Author(s)
      Takuii Tanaka, et al.
    • Journal Title

      Carcinogenesis 26(1)

      Pages: 229-238

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice : attenuation of pro-inflammatory gene expression.2005

    • Author(s)
      Ki Han Kwon, et al.
    • Journal Title

      Biochem.Pharmacol. 69(3)

      Pages: 395-406

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of α-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats.2005

    • Author(s)
      Shigeyuki Sugie, et al.
    • Journal Title

      Int.J.Cancer (in press)

      Pages: 110-110

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.2005

    • Author(s)
      Koujiro Yoshida, et al.
    • Journal Title

      Cancer Lett. (in press)

      Pages: 215-215

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane.2005

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Histol.Histopathol. (in press)

      Pages: 19-19

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] β-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.2005

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. (in press)

      Pages: 96-96

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-α-expressing oval-like cells and activated hepatic stellate cells.2005

    • Author(s)
      Tetsuro Sano, et al.
    • Journal Title

      Nutr.Cancer 51(2) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Potent chemopreventive agents against pancreatic cancer2004

    • Author(s)
      Akiyoshi Nishikawa, et al.
    • Journal Title

      Current Cancer Drug Targets 4

      Pages: 373-384

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cigarette smoking, metabolic activation and carcinogenesis2004

    • Author(s)
      Kiyoshi Nishikawa, et al.
    • Journal Title

      Curr.Drug Metab. 5

      Pages: 363-373

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Extract of venegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells2004

    • Author(s)
      Kumiko Nanda, et al.
    • Journal Title

      J.Exp.Clin.Cancer Res. 23

      Pages: 69-75

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation2004

    • Author(s)
      Masataka Kagawa, et al.
    • Journal Title

      Carcinogenesis 25

      Pages: 979-985

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice2004

    • Author(s)
      Akira Murakami, et al.
    • Journal Title

      Int.J.Cancer 110

      Pages: 481-490

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component biobalide on azoxymethane-induced colonic aberrant crypt foci in rats2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Cancer Lett. 210

      Pages: 159-169

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 481-486

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Preventive effects of powdered broccoli sprout on azoxymethane-induced rat colonic aberrant crypt foci2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      J.Toxicol.Pathol. 17

      Pages: 119-126

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 721-727

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells2004

    • Author(s)
      Masashi Hosokawa, et al.
    • Journal Title

      Biochim.Biophys.Acta 1675

      Pages: 113-119

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism2004

    • Author(s)
      Midori Yoshida, et al.
    • Journal Title

      Carcinogenesis 25

      Pages: 2257-2264

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Biofactors 21

      Pages: 111-114

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lack of modifying effects of 4-tert-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 300-305

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice2004

    • Author(s)
      Yoshinobu Hirose, et al.
    • Journal Title

      Carcinogenesis 25

      Pages: 821-825

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats2004

    • Author(s)
      Yumi Shimoji, et al.
    • Journal Title

      Nutr.Cancer 49

      Pages: 170-173

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats2004

    • Author(s)
      Takuji Tanaka, et al.
    • Journal Title

      Cancer Lett. 210

      Pages: 129-137

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis2004

    • Author(s)
      Keiko Sakata, et al.
    • Journal Title

      Oncology 66

      Pages: 244-252

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARγ expression and alteration of lipid composition2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Int.J.Cancer 110

      Pages: 896-901

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice2004

    • Author(s)
      Ki Han Kwon, et al.
    • Journal Title

      Biofactors 21

      Pages: 179-184

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] フラボノイドの生理活性2004

    • Author(s)
      田中卓二, 他
    • Journal Title

      Food & Food Ingredients Journal of Japan 209

      Pages: 472-480

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 特集 がんの化学予防:動物実験によるスクリーニング2004

    • Author(s)
      田中卓二
    • Journal Title

      最新医学 59

      Pages: 2396-2402

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Potent chemopreventive agents against pancreatic cancer.2004

    • Author(s)
      Akiyoshi Nishikawa, et al.
    • Journal Title

      Current Cancer Drug Targets 4(4)

      Pages: 373-384

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cigarette smoking, metabolic activation and carcinogenesis.2004

    • Author(s)
      Akiyoshi Nishikawa, et al.
    • Journal Title

      Curr.Drug Metab. 5(5)

      Pages: 363-373

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.2004

    • Author(s)
      Kumiko Nanda, et al.
    • Journal Title

      J.Exp.Clin.Cancer Res. 23(1)

      Pages: 69-75

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation.2004

    • Author(s)
      Masataka Kagawa, et al.
    • Journal Title

      Carcinogenesis 25(6)

      Pages: 979-985

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.2004

    • Author(s)
      Akira Murakami, et al.
    • Journal Title

      Int.J.Cancer 110(4)

      Pages: 481-490

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component biobalide on azoxymethane-induced colonic aberrant crypt foci in rats.2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Cancer Lett. 210(2)

      Pages: 159-169

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lack of modifying effects of 4-tert-octylphenol and benzyl butyl phthalate on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats.2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. 95(4)

      Pages: 300-305

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice.2004

    • Author(s)
      Yoshinobu Hirose, et al.
    • Journal Title

      Carcinogenesis 25(5)

      Pages: 821-825

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.2004

    • Author(s)
      Yumi Shimoji, et al.
    • Journal Title

      Nutr.Cancer 49(2)

      Pages: 173

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats.2004

    • Author(s)
      Takuji Tanaka, et al.
    • Journal Title

      Cancer Lett. 210(2)

      Pages: 129-137

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine -induced rat hepatocarcinogenesis.2004

    • Author(s)
      Keiko Sakata, et al.
    • Journal Title

      Oncology 66(3)

      Pages: 244-252

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARγ expression and alteration of lipid composition.2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Int.J.Cancer 110(6)

      Pages: 896-901

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats2004

    • Author(s)
      Hiroyuki Kohno, et al.
    • Journal Title

      Cancer Sci. 95(6)

      Pages: 481-486

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Preventive effects of powdered broccoli sprout on azoxymethane-induced rat colonic aberrant crypt foci.2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      J.Toxicol.Pathol. 17(2)

      Pages: 119-126

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate.2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Cancer Sci. 95(9)

      Pages: 721-727

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells.2004

    • Author(s)
      Masashi Hosokawa, et al.
    • Journal Title

      Biochem.Biophys.Acta 1675(1-3)

      Pages: 113-119

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism.2004

    • Author(s)
      Midori Yoshida, et al.
    • Journal Title

      Carcinogenesis 25(11)

      Pages: 2257-264

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.2004

    • Author(s)
      Rikako Suzuki, et al.
    • Journal Title

      Biofactors 21(1-4)

      Pages: 111-114

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Suppressive activity of a fermented grain food product on dextran sulfate sodium-induced experimental colitis in mice.2004

    • Author(s)
      Ki Han Kwon, et al.
    • Journal Title

      Biofactors 21(1-4)

      Pages: 179-184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] フラボノイドの生理活性.2004

    • Author(s)
      田中卓二、他
    • Journal Title

      Food & Food Ingredients Journal of Japans 209(6)

      Pages: 472-480

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 特集 がんの化学予防 : 動物実験によるスクリーニング.2004

    • Author(s)
      田中卓二
    • Journal Title

      最新医学 59(11)

      Pages: 2396-2402

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2006-07-11  

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