2005 Fiscal Year Final Research Report Summary
Changes in the Cerebral Oxygen Environment during Psychosedation Sedation : Evaluation using a Near-Infrared Oxygenation Monitor
| Project/Area Number |
15592129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SHINOHE Yutaka Iwate Medical University, School of Dentistry, Lecturer, 歯学部, 講師 (30347885)
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| Co-Investigator(Kenkyū-buntansha) |
JOH Shigeharu Iwate Medical University, School of Dentistry, Professor, 歯学部, 教授 (20154411)
SATOH Masahito Iwate Medical University, School of Dentistry, Associate professor, 歯学部, 助教授 (60215845)
SATOH Kenichi Iwate Medical University, School of Dentistry, Lectuer, 歯学部, 講師 (90265174)
SAKAMOTO Nozomu Iwate Medical University, School of Dentistry, Assistant, 歯学部, 助手 (70285641)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Near-Infrared Oxygenation Monitor / Psychosedation / Cerebral Oxygen / clinical dentistry |
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| Research Abstract |
We investigated the change of the intracerebral oxygen environment during inhalation sedation with nitrous oxide(I) and intravenously injected with abirritants (Midazolam : MD- ; 0.03mg/kg,0.05mg/kg, 0.07mg/kg group, Propofol : PRF- ; 1〜3 mg/kg/hrgroup) (II) using a near-infrared oxygen monitor (NIRO).
Results
I. 1.In both groups, SBP, DBP and HR did not change significantly throughout the experiment.2. In both groups, ETCO_2 increased gradually and significantly by the room air inhalation after a mixed-gas inhalation and there was also a significant difference between the two groups.3. TCPO_2 showed a trend that decreases gradually by the room air inhalation after a mixed-gas inhalation but there was no significant difference between the tow groups.4. HbO_2 had a significant fall by room air inhalation after a mixed-gas inhalation in N2O group and there was also a significant difference between the two groups.5. Δ Cytaa3 did not change significantly throughout the experiment in both gro
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ups, and there was no significant difference between the two groups.
II. 1. ETCO_2 and TCPCO_2 increased gradually under administration. After administration was halted, ETCO_2 and TCPCO_2began to decrease promptly and recovered to the original status after 10 minutes. 2. SpO_2 and TCPO_2 decreased gradually under administration. 3. HbO_2 increased gradually from 5 to 17 minutes and then decreased gradually from 18 to 38 minutes. 4. Δ Cytaa3 did not change significantly throughout the experiment.
Conclusion
In conclusion, during and after nitrous oxide inhalation sedation and during and after intravenous sedation in clinical dentistry, although the oxygen content in blood fell, a satisfactory intracerebral oxygen environment was maintained.
Therefore, the results of this study suggest that the partial pressure of oxygen in arterial blood will not fall from change of SpO_2 and TcPO_2, but cerebral partial pressure of oxygen falls due to the significant fall of HbO2 following inhalation of the room air after 30% of nitrous oxide inhalation. However it is believed that hypoxia of cerebral tissue does not occur from the change of Δ Cytaa3. Less
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Research Products
(2 results)
