2016 Fiscal Year Annual Research Report
| Project/Area Number |
15F14409
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
林 康紀 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (90466037)
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| Co-Investigator(Kenkyū-buntansha) |
LUCHETTI ALESSANDRO 国立研究開発法人理化学研究所, 脳科学総合研究センター, 外国人特別研究員
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| Project Period (FY) |
2015-04-24 – 2017-03-31
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| Keywords | セロトニン / in vivo イメージング / バーチャルリアリティー / 海馬 |
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| Outline of Annual Research Achievements |
During FY 2016 we continued the investigation of serotonergic (5HT) fibres activity in CA1.
Using in vivo 2 photon calcium imaging we observed that these fibres fire according to one of two activity patterns. The first and most common pattern consists of increased firing when the animal is about to start locomotion. This pattern also seems to display strong bursting at the end of long periods of inactivity, as well as irregular activity when the animal is inactive. The second pattern does not respond to locomotion, but to reward delivery instead.
Using what we observed, we built a model to describe where the greatest activity of CA1 5HT fibers would occur, and tested whether artificially stimulating these fibres could boost spatial memory.
Local optogenetic stimulation of CA1 5HT fibres during a spatial memory task led to a consistent increase in goal zone preference and other parameters, supporting a role in encoding rewarded locations.
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| Research Progress Status |
28年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
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