2017 Fiscal Year Annual Research Report
マヌカハニー摂取による大腸がん予防機構の解明に向けたニュートリオミクス研究
| Project/Area Number |
15F15395
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| Research Institution | Keio University |
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Principal Investigator |
冨田 勝 慶應義塾大学, 環境情報学部(藤沢), 教授 (60227626)
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| Co-Investigator(Kenkyū-buntansha) |
AW WANPING 慶應義塾大学, 環境情報学部(藤沢), 外国人特別研究員
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| Project Period (FY) |
2015-11-09 – 2018-03-31
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| Keywords | Rice Bran / Gut microbiota / Metabolome / Metagenome / Multi-omics |
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| Outline of Annual Research Achievements |
In this year, we conducted a screening experiment using different food products (Manuka Honey, Rice Bran and Soy Beans) in the animal models that we have created in last year.Unfortunately, Manuka Homey and Soy Beans supplementation did not improve colitis. As such, we aimed to elucidate the molecular mechanisms of Oryza sativa, rice bran(RB) dietrary intervention on 2.0% dextran sulfate sodium (DSS)-included colitis C57BL/6L mice mode. Body weight loss, disease activity index, colon length and colon histopathology were improved in BR-fed mice. Time-course microbiome and metabolome results suggest that RB-related alterations of gut environment can prevent colitis via establishing gut homeostasis. Our approach is an important tool in developing new therapeutic applications of RB.
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| Research Progress Status |
29年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
29年度が最終年度であるため、記入しない。
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