2007 Fiscal Year Final Research Report Summary
Pheromonal control of the hypothalamo-limbic function
Project/Area Number |
15GS0306
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Research Category |
Grant-in-Aid for Creative Scientific Research
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Allocation Type | Single-year Grants |
Research Institution | The University of Tokyo |
Principal Investigator |
MORI Yuji The University of Tokyo, Graduate School of Agricultural and Life Sciences, professor (40157871)
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Co-Investigator(Kenkyū-buntansha) |
WATANABE Hidenori The University of Tokyo, Graduate School of Agricultural and Life Sciences, professor (00202416)
ICHIKAWA Masumi Tokyo Metropolitan Organization for Medical Research, Tokyo Metropolitan Institute for Neuroscience, Department for Neuroscience Basic Technology, Director (20124414)
OKAMURA Hiroaki National Institute of Agrobiological Sciences, Division of Animal Sciences Neurobiology Research Unit, Head researcher (60213972)
TAKEUCHI Yukari The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate professor (10240730)
KIKUSUI Takehumi Azabu University, School of Veterinary Medicine, Associate Professor (90302596)
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Project Period (FY) |
2003 – 2007
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Keywords | mammals / primer pheromone / structure determination / chemical synthesis / limbic-hypothalamic system / neuroethology / pheromone receptor / mechanism of pheromone production |
Research Abstract |
Primer pheromones profoundly influence the brain function and thereby induce various physiological as well as behavoral responses in mammals. Although such phenomena have long been documented, little is known about mammalian primer pheromones. The present study was conducted in order to draw a comprehensive picture of chemical communication via pheromones in mammalian species by focusing on two representative pheromone models, namely the "male effect" pheromone in ruminants and "alarm" pheromone in rodents. We investigated mechanisms of production, perception, neural pathway of these pheromones, and also tried to isolate and identify responsible molecules as pheromone candidates. The "male effect" is a pheromone-induced gonadal activation, which is particularly well known in sheep and goats. The hypothalamic GnRH pulse generator is the target of this pheromone action. We have revealed that the pheromone is perceived by V1R receptors located at both the vomeronasal and olfactory epitheli
… More
um. Pheromone information is then transmitted via amygdala to the arcuate nucleus of the hypothalamus and stimulates the kisspeptin neuron, which is found to play a key role in generating the pulsatility of GnRH neurosecretion. During the term of this research project we could isolate and identify 16 candidate pheromone substances, of which mixture shows "male effect" pheromone like activity. The "alarm" pheromone is, on the other hand, an olfactory signal, which is emitted from stressed animal for dissemination of potential dangers to family or group members. We have cralified that the pheromone is a water soluble volatile substance released from the peri-anal gland of the donor animal and it is perceived by the vomeronasal organ of the recipient, of which anxiety level is elevated resulting in the increase of risk-assessment as well as defensive behaviors and exacerbation of accompanying autonomic responses. By establishing a bioassay system for the alarm pheromone with measurement of the acoustic startle response we could isolate a candidate pheromone substance, which is currently under investigation for its chemical structure. Less
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Research Products
(335 results)
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[Journal Article] Modulation of GnRH pulse generator activity by the pheromone in small ruminants2009
Author(s)
Murata K, Wakabayashi Y, Kitago M., Ohara H., Watanabe H., Tamogami S., Warita Y, Yamagishi K., Ichikawa M., Takeuchi Y, Okamura H., Mori Y.
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Journal Title
J Neuroendocrinol 21
Pages: 346-350
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Central Administration of Neuropeptide B, But not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep2008
Author(s)
Mogi K., Ito S., Matsuyama S., Ohara H., Sakumoto R., Yayon K., Ohkura S., Sutoh M., Mori Y., Okanmra H.
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Journal Title
J Reprod Dev 54
Pages: 138-141
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Central administration of neuropeptide B, but not prolactin-releasing peptide, stimulates cortisol secretion in sheep2008
Author(s)
Mogi K., Ito S., Matsuyama S., Ohara IT., Sakumoto R., Yayou K., Ohkura S., Sutoh M., Mori Y., Okamura H.
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Journal Title
J Reprod Dev 54
Pages: 138-141
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Androgen induces production of male effect pheromone in female goats2007
Author(s)
Kakuma Y., Ichimaru T., Yonezawa T., Momozawa Y., Hashizume C., Iwata E., Kikusui T., Takeuehi Y., Ohkura S., Okamura H., Mori Y.
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Journal Title
J Reprod Dev 53
Pages: 829-834
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Androgen induces production of male effect pheromone in female goats2007
Author(s)
Kakuma Y., Ichimaru T., Yonezawa T., Momozawa Y, Hashizume C, Iwata E., Kikusui T., Takeuchi Y, Ohkura S., Okamura H., Mori Y.
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Journal Title
J Reprod Dev 53
Pages: 829-834
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Gene expression profiles linked to the hormonal induction of male-effect pheromone synthesis in goats (Capra hircus)2007
Author(s)
Momozawa Y, Takeuchi Y, Kitago M., Masuda K., Kakuma Y, Hashizume C, Ichimaru T., Mogi K., Okamura H., Yonezawa T., Kikusui T., Mori Y.
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Journal Title
Biol Reprod 77
Pages: 102-107
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 抗ヤキメタスチン抗体の作製2008
Author(s)
大蔵聡, 高瀬健志, 束村博子, 前多敬一郎, 岡村裕昭
Organizer
日本畜産学会第109回大会
Place of Presentation
茨城県水戸市常磐大学
Year and Date
2008-03-27
Description
「研究成果報告書概要(和文)」より
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[Presentation] 2007. Alarm pheromone in male rats2007
Author(s)
Kiyokawa Y, Inagaki H., Kikusui T, Takeuchi Y, Mori Y.
Organizer
Topics of taste and olfaction studies by young researchers
Place of Presentation
Tokyo, Japan
Year and Date
2007-07-26
Description
「研究成果報告書概要(欧文)」より
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[Presentation] シバヤギ雄効果フェロモン合成酵素群の同定の試み2006
Author(s)
北郷潤, 桃沢幸秀, 若林嘉浩, 伊藤敦子, 山岸公子, 岡村裕昭, 菊水健史, 武内ゆかり, 森裕司
Organizer
第99回日本繁殖生物学会大会
Place of Presentation
愛知県名古屋市千種区名古屋大学野依記念学術交流館
Year and Date
2006-09-07
Description
「研究成果報告書概要(和文)」より
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[Presentation] ウシフェロモン受容体の発現解析2006
Author(s)
流石慎太郎, 日高翔, 若林嘉弘, 大迫俊治, 市川眞澄, 大蔵聡, 岡村裕昭, 猪飼篤, 長田俊哉
Organizer
日本味と匂学会第40回記念大会
Place of Presentation
福岡県福岡市九州大学医学部百年講堂
Year and Date
2006-07-11
Description
「研究成果報告書概要(和文)」より
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[Presentation] イモリ鋤鼻受容体遺伝子の解析2006
Author(s)
山岸公子, 伊藤敦子, 市川眞澄, 森裕司
Organizer
日本味と匂学会第40回記念大会
Place of Presentation
福岡県福岡市九州大学医学部百年講堂
Year and Date
2006-07-11
Description
「研究成果報告書概要(和文)」より
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[Presentation] ヤギの季節繁殖の制御機構2006
Author(s)
安尾しのぶ, 中尾暢宏, 大蔵聡, 飯郷雅之, 織田銑一, 前多敬一郎, 崇山, 渡邊美和, 渡辺剛史, 岡村裕昭, 海老原史樹文, 吉村
Organizer
日本畜産学会第106回大会
Place of Presentation
福岡県福岡市九州大学六本松キャンパス
Year and Date
2006-03-29
Description
「研究成果報告書概要(和文)」より
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[Presentation] 痛覚刺激時の脳脊髄液中および血漿中オキシトシン濃度の変化2006
Author(s)
矢用健一, 尹藤秀一, 中村正斗, 粕谷悦子, 角川博哉, 河合宏篤, 吉岡耕治, 新井鐘蔵, 鈴木千恵, 大蔵聡, 岡〓
Organizer
日本畜産学会第106回大会
Place of Presentation
福岡県福岡市九州大学六本松キャンパス
Year and Date
2006-03-29
Description
「研究成果報告書概要(和文)」より
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[Presentation] 主嗅覚系におけるフェロモン認知の可能性2006
Author(s)
伊藤敦子, 齋藤正一郎, 市川眞澄, 森裕司, 山岸公子
Organizer
低次脳機能研究会主催シンポジウム「生命の基本を司る本能的脳機構」
Place of Presentation
埼玉県さいたま市ソニックシティホール
Year and Date
2006-01-06
Description
「研究成果報告書概要(和文)」より
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[Presentation] 雄効果フェロモン活性画分の部分精製2005
Author(s)
増田宏司, 茂木一孝, 市丸徹, 冨松理, 国吉栄喜, 菊水健史, 武内ゆかり, 大蔵聡, 岡村裕昭, 石神健, 渡邊秀典, 森裕司
Organizer
第140回日本獣医学会学術集会
Place of Presentation
鹿児島県鹿児鳥市かごしま県民交流センター
Year and Date
2005-09-29
Description
「研究成果報告書概要(和文)」より
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[Presentation] ヤギ副嗅球の組織学的特徴2005
Author(s)
茂木一孝, 市丸徹, 大蔵聡, 森裕司, 岡村裕昭
Organizer
第140回日本獣医学会学術集会
Place of Presentation
鹿児島県鹿児島市かごしま県民交流センター
Year and Date
2005-09-29
Description
「研究成果報告書概要(和文)」より
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[Presentation] ヤギの雄効果フェロモン合成に関わる遺伝子の探索2005
Author(s)
桃沢幸秀, 橋爪(茂木)千恵, 増田宏司, 加隈良枝, 茂木一孝, 酒向隆司, 菊水健中, 武内ゆかり, 森裕司
Organizer
第105回日本畜産学会大会
Place of Presentation
北海道札幌市札幌コンベンションセンター
Year and Date
2005-09-09
Description
「研究成果報告書概要(和文)」より
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[Presentation] 哺乳類のフェロモンと行動2005
Author(s)
森裕司
Organizer
東京農業大学家畜育種学研究室特別講演
Place of Presentation
神奈川県厚木市東京農業大学
Year and Date
2005-07-27
Description
「研究成果報告書概要(和文)」より
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[Presentation] Vomeronasal system in domestic animals2004
Author(s)
Okamura H., Ohkura S., Mori Y.
Organizer
Satellite Symposium of the JSAR Annual Meeting 2004-Current Status and Perspectives in Reproductive Biology and Biotechnology
Place of Presentation
Kyoto, Japan
Year and Date
20040919-20040920
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Vomeronasal system in domestic animals2004
Author(s)
Okamura H., Ohkura S., Mori Y.
Organizer
第97回日本繁殖生物学会大会サテライトシンポジウムCurrent Status and Perspectives in Reproductive Biology and Biotechnology
Place of Presentation
京都府京都市京都大学医学部芝蘭会館
Year and Date
2004-09-19
Description
「研究成果報告書概要(和文)」より
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[Presentation] ヤギ副嗅球からの神経投射経路の解析2004
Author(s)
岡村裕昭, 櫻井勝康, 市丸徹, 茂木一孝, 森裕司, 大蔵聡
Organizer
第8回鋤鼻研究会
Place of Presentation
石川県羽咋郡いこいの村能登半島
Year and Date
2004-06-10
Description
「研究成果報告書概要(和文)」より
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[Presentation] ヤギ副嗅球の組織化学的解析2004
Author(s)
茂木一孝, 櫻井勝康, 市丸徹, 大蔵聡, 森裕司, 岡村裕昭
Organizer
第8回鋤鼻研究会
Place of Presentation
石川県羽咋郡いこいの村能登半島
Year and Date
2004-06-10
Description
「研究成果報告書概要(和文)」より
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[Presentation] 哺乳類のフェロモンと行動2003
Author(s)
森裕司
Organizer
第26回日本分子生物学会年会
Place of Presentation
兵庫県冲戸市神戸ポートアイランド
Year and Date
2003-12-10
Description
「研究成果報告書概要(和文)」より
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[Presentation] 歩み"-遥かなる副嗅球への道のり-2003
Author(s)
桜井勝康, 大蔵聡, 松山秀一, 市丸徹, 矢用健一, 小原嘉昭, 岡村裕昭
Organizer
第7回鋤鼻研究会
Place of Presentation
神奈川県足柄郡
Year and Date
2003-06-19
Description
「研究成果報告書概要(和文)」より
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