Development of species/site-specific drug delivery technology using carrier particles and their application to agriculture field

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H01745
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental engineering and reduction of environmental burden
• Research Institution: Osaka Prefecture University
• Principal Investigator: Nomura Toshiyuki 大阪府立大学, 工学(系)研究科(研究院), 准教授 (00285305)
• Co-Investigator(Kenkyū-buntansha): 谷 修治 大阪府立大学, 生命環境科学研究科, 准教授 (80405357) ; 徳本 勇人 大阪府立大学, 理学(系)研究科(研究院), 講師 (70405348)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: キャリア粒子 / DDS / 植物 / イメージング

Outline of Final Research Achievements

In this study, the delivery of target substances to cells with cell walls was investigated using carrier particles. As a result, it was found that biodegradable polymer particles were taken into plant pathogens. In addition, it was revealed that encapsulation of pesticide in the carrier particle improved the inhibition of infection by plant pathogens. Furthermore, it was found that proteins and polysaccharides can be delivered to plant cells by using polystyrene particles (particle size 30 nm) adsorbing cationic lipids as carrier particles.

Free Research Field

粒子ー細胞間に働く相互作用力の評価と応用