2017 Fiscal Year Final Research Report
Development of versatile synthesis for fungal natural products by reconstitution of biosynthetic machinery
| Project/Area Number |
15H01835
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南 篤志 北海道大学, 理学研究院, 准教授 (40507191)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 生合成 / 天然物 / テルペン / ペプチド / 麹菌 |
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| Outline of Final Research Achievements |
Using Aspergillus oryzae expression system, we have succeeded elucidation of enzymatic mechanism of several important natural products such as C20/C25-terpenes, ribosomal peptide and mushroom antibiotics. Especially, we proved the expression system is reliable for production of known and novel natural products (terpenoids) using uncharacterized biosynthetic gene clusters.
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| Free Research Field |
生物有機化学
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