2017 Fiscal Year Final Research Report
Development of highly sensitive chemical detection of the nucleic acid methylations strongly affecting lifestyle diseases
| Project/Area Number |
15H02190
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bio-related chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Okamoto Akimitsu 東京大学, 先端科学技術研究センター, 教授 (60314233)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | DNA / メチル化 / 脱メチル化 / ヒストン / 金属反応 / ペプチド合成 |
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| Outline of Final Research Achievements |
Based on the chemical reactions developed by us, the studies on highly efficient detection methods for epigenetic modifications have been carried out. The results are as follows: (i) Highly bright detection of methylation in DNA repeat sequences to understand heterogeneity in tumors, (ii) High performance analysis of the products in demethylation process to make prognostication for tumors efficient, (iii) Chemical reproduction and analysis of histone structures for control of gene expression.
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| Free Research Field |
生物有機化学
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