2019 Fiscal Year Final Research Report
Molecular mechanism of signal transduction regulating axon regeneration
| Project/Area Number |
15H02388
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Keywords | 遺伝学 / 再生医学 / シグナル伝達 / 神経科学 / 脳・神経 |
|---|
| Outline of Final Research Achievements |
The ability of axons to regenerate after damage is a fundamental and conserved property of neurons governed by intrinsic processes that regulate axon growth potential. However, these intrinsic signaling mechanisms have yet to be fully elucidated. The nematode Caenorhabditis elegans has recently emerged as an attractive model to dissect the mechanisms of axon regeneration in the mature nervous system. In this study, we identified a number of genes that regulate axon regeneration in C. elegans. Analysis of these genes shed new light on the regulation of axonal regeneration.
|
| Free Research Field |
シグナル伝達
|
| Academic Significance and Societal Importance of the Research Achievements |
神経軸索の再生機構の研究は、医学的には事故や疾患による神経切断や欠損の治療法を開発する上で重要であり、社会的にも喫緊の課題である。本研究により、線虫から哺乳動物まで種を超えて保存された、神経の軸索再生を制御するシグナル伝達ネットワークが解明された。今後、本研究で得られた成果は、ヒトの脊髄損傷などの神経損傷患者の治療研究の糸口になるものと期待される。
|
