Risk assessment of vector control chemicals to wild animals and development of novel method to determine the chemical sensitivity

2017 Fiscal Year Annual Research Report

• Project/Area Number: 15H02825
• Research Institution: Hokkaido University
• Principal Investigator: 池中 良徳 北海道大学, 獣医学研究院, 准教授 (40543509)
• Co-Investigator(Kenkyū-buntansha): 石塚 真由美 北海道大学, 獣医学研究院, 教授 (50332474) ; 水川 葉月 北海道大学, 獣医学研究院, 助教 (60612661) ; 中山 翔太 北海道大学, 獣医学研究院, 助教 (90647629)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: Vector Control / DDT / 室内限定散布 / リスク評価 / ケミカルハザード / オミクス

Outline of Annual Research Achievements

Vector Controlは人類にとって極めて緊急性の高い課題であり、種々の対策案が検討され実施されてきているが、DDTやピレスロイド等の薬剤散布は経済的benefitの観点から未だに主流である。これらの薬剤は、世界的に猛威を振るうマラリアによる死亡率を短期間で減少させ、一定のbenefitを挙げている事は事実である。しかし、化学物質の中・長期的継続使用には高いriskをヒトや野生動物に与える可能性がある。以上の背景をもとに、当該研究の目的はVector Controlに用いられるDDTやピレスロイドのヒトや家禽、希少野生動物に対する新規毒性影響評価手法を確立し、そのriskを明らかにする事である。
当該研究では、上記目的を達成するため、特に家禽であるニワトリに着目し、蓄積するDDT濃度を測定したうえで、未だ確立していないDDTに対するバイオマーカーの探索をマルチオミクス解析により実施した。
蓄積するDDT濃度に対する各遺伝子発現量を解析した結果、免疫関連遺伝子（AvBD1、2、6、7）とDDT濃度には負の相関が確認された。一方、脂質代謝や合成に関与するIGFBP1、ELOVL2およびSQLEまたステロイド代謝に関与するCYP17A1とDDT濃度には有意な正の相関が確認された。特に、CYP17A1とDDT濃度の相関係数はR2=0.86と特に強い正の相関があり、ステロイドホルモン合成が攪乱されている事が示唆された。CYP17A1はアンドロゲンホルモンの合性に関与しており、鳥類において性分化にも関与している遺伝子である。
当該研究で得られた結果は、Vector Controlのために散布しているDDTがニワトリにおける遺伝子発現を攪乱している可能性を世界に先駆け示す結果であった。

Research Progress Status

29年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

29年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] North-West University/Johannesburg University(South Africa)
  • Country Name: South Africa
  • Counterpart Institution: North-West University/Johannesburg University
• [Int'l Joint Research] Gondar University(Ethiopia)
  • Country Name: Ethiopia
  • Counterpart Institution: Gondar University
• [Int'l Joint Research] Zagazig University(Egypt)
  • Country Name: Egypt
  • Counterpart Institution: Zagazig University
• [Int'l Joint Research] University of Benin(Nigeria)
  • Country Name: Nigeria
  • Counterpart Institution: University of Benin
• [Int'l Joint Research] KNUST(Ghana)
  • Country Name: Ghana
  • Counterpart Institution: KNUST
• [Journal Article] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species (2018)
  • Author(s): Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M.
  • Journal Title: Comparative Biochemistry and Physiology part c Volume: accepted Pages: accepted
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Human Health Risk from Consumption of Marine Fish Contaminated with DDT and Its Metabolites in Maputo Bay, Mozambique (2018)
  • Author(s): Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、Ichise T.、Ito G.、Bortey-Sam N.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M.
  • Journal Title: Bulletin of Environmental Contamination and Toxicology Volume: 100 Pages: 672-676
  • DOI: 10.1007/s00128-018-2323-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia (2018)
  • Author(s): Yabe John、Nakayama Shouta M.M.、Ikenaka Yoshinori、Yohannes Yared B.、Bortey-Sam Nesta、Kabalo Abel Nketani、Ntapisha John、Mizukawa Hazuki、Umemura Takashi、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 202 Pages: 48～55
  • DOI: https://doi.org/10.1016/j.chemosphere.2018.03.079
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens (2018)
  • Author(s): Ishii C、Ikenaka Y、Ichii O、Nakayama S M M、Nishimura S-I、Ohashi T、Tanaka M、Mizukawa H、Ishizuka M
  • Journal Title: Poultry Science Volume: 97 Pages: 1722-1729
  • DOI: https://doi.org/10.3382/ps/pey016
  • Peer Reviewed
• [Journal Article] Biomarkers in tigerfish (Hydrocynus vittatus) as indicators of metal and organic pollution in ecologically sensitive subtropical rivers (2018)
  • Author(s): R. Gerber、N.J. Smit、Johan H.J. van Vuren、Y. Ikenaka、Victor Wepener
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 157 Pages: 307-317
  • DOI: https://doi.org/10.1016/j.ecoenv.2018.03.091
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fish consumption from urban impoundments: What are the health risks associated with DDTs and other organochlorine pesticides in fish to township residents of a major inland city (2018)
  • Author(s): Pheiffer Wihan、Wolmarans Nico J.、Gerber Ruan、Yohannes Yared B.、Ikenaka Yoshinori、Ishizuka Mayumi、Smit Nico J.、Wepener Victor、Pieters Rialet
  • Journal Title: Science of the Total Environment Volume: 628-629 Pages: 517～527
  • DOI: https://doi.org/10.1016/j.scitotenv.2018.02.075
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana (2018)
  • Author(s): Bortey-Sam Nesta、Ikenaka Yoshinori、Akoto Osei、Nakayama Shouta M.M.、Asante Kwadwo A.、Baidoo Elvis、Obirikorang Christian、Mizukawa Hazuki、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 235 Pages: 163～170
  • DOI: 10.1016/j.envpol.2017.12.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle (2018)
  • Author(s): Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo JT, Saengtienchai A, Mizukawa H, Ishizuka M
  • Journal Title: JVMS Volume: 80 Pages: 375-381
  • DOI: 10.1292/jvms.17-0410.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line. (2018)
  • Author(s): Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Thompson LA, Ishizuka M
  • Journal Title: Environ Sci Pollut Res Int. Volume: 25 Pages: 6320-6328
  • DOI: 10.1007/s11356-017-0977-z.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 鳥類で起こっているケミカルハザードとそのメカニズム (2017)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Journal Title: 日本野生動物医学会誌 Volume: 22 Pages: 69-72
• [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores (2017)
  • Author(s): Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
  • Journal Title: Toxicological Sciences Volume: 158 Pages: 90～100
  • DOI: 10.1093/toxsci/kfx072
  • Peer Reviewed / Open Access
• [Journal Article] Anthropogenic and Naturally Produced Brominated Phenols in Pet Blood and Pet Food in Japan (2017)
  • Author(s): Mizukawa Hazuki、Nomiyama Kei、Nakatsu Susumu、Yamamoto Miyuki、Ishizuka Mayumi、Ikenaka Yoshinori、Nakayama Shouta M.M.、Tanabe Shinsuke
  • Journal Title: Environ. Sci. Technol. Volume: 51 Pages: 11354～11362
  • DOI: 10.1021/acs.est.7b01009
  • Peer Reviewed
• [Journal Article] Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa (2017)
  • Author(s): Yohannes Yared Beyene、Ikenaka Yoshinori、Ito Gengo、Nakayama Shouta M. M.、Mizukawa Hazuki、Wepener Victor、Smit Nico J.、Van Vuren Johan H. J.、Ishizuka Mayumi
  • Journal Title: Environmental Science and Pollution Research Volume: 24 Pages: 23763～23770
  • DOI: 10.1007/s11356-017-9911-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concentrations and human health risk assessment of DDT and its metabolites in free-range and commercial chicken products from KwaZulu-Natal, South Africa (2017)
  • Author(s): Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M.
  • Journal Title: Food Additives and Contaminants: Part A Volume: 34 Pages: 1959～1969
  • DOI: https://doi.org/10.1080/19440049.2017.1357209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 非実験動物における化学物質代謝能の特徴と種差 (2017)
  • Author(s): Mizukawa Hazuki、Ikenaka Yoshinori、Kakehi Mayu、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: Yakugaku Zasshi Volume: 137 Pages: 257～263
  • DOI: 10.1248/yakushi.16-00230-2
• [Journal Article] Organochlorine pesticide contamination of foods in Africa: incidence and public health significance (2017)
  • Author(s): THOMPSON Lesa A.、DARWISH Wageh Sobhy、IKENAKA Yoshinori、NAKAYAMA Shouta M. M.、MIZUKAWA Hazuki、ISHIZUKA Mayumi
  • Journal Title: JVMS Volume: 79 Pages: 751～764
  • DOI: 10.1292/jvms.16-0214
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia (2017)
  • Author(s): Yohannes Yared Beyene、Ikenaka Yoshinori、Nakayama Shouta M.M.、Mizukawa Hazuki、Ishizuka Mayumi
  • Journal Title: Science of the Total Environment Volume: 574 Pages: 1389～1395
  • DOI: https://doi.org/10.1016/j.scitotenv.2016.08.056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Lead levels in eggs in Kabwe, Zambia: implication of human exposure (2018)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
  • Organizer: Society of Toxicology’s 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Novel Mechanism of Rodenticide (warfarin) Resistance of Wild Rats in Tokyo ~ Enhanced Pentose Phosphate Pathway Causes Rapid Metabolism of Warfarin ~ (2018)
  • Author(s): Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: Society of Toxicology’s 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Comparison of Food Products Contaminated by DDTs in South Africa and Mozambique (2017)
  • Author(s): Lesa A. Thompson, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
  • Organizer: 19th International Conference on One Health
  • Int'l Joint Research
• [Presentation] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル（BDE209）は甲状腺機能亢進症を引き起こすのか？ (2017)
  • Author(s): 水川葉月、野見山桂、池中良徳、中山翔太、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、笹岡一慶、市居修、Kraisiri Khidkhan、高居名菜、滝口満喜、田辺信介、石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] 血清中メタボローム解析によるイエネコのPCBs毒性影響評価 (2017)
  • Author(s): 野見山桂、西川 博之、水川葉月、髙口倖暉、Tsend-ayush Sainnoxoi、横山 望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] PCBs曝露がイヌ・ネコの甲状腺ホルモン恒常性へ及ぼす影響 (2017)
  • Author(s): 髙口倖暉、野見山桂、西川博之、水川葉月、田上瑠美、芳之内結加、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、岩田久人、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] イエネコのin vivo長期曝露試験：デカブロモジフェニルエーテル(BDE209)の生体内変化 (2017)
  • Author(s): 田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、Aksorn Saengtienchai、Tsend-ayush Sainnoxoi、横山望、市居修、滝口満喜、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
  • Organizer: 第26回環境化学討論会
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] ヒト生体試料を用いたネオニコチノイドおよびネオニコチノイド代謝物の分析方法 (2017)
  • Author(s): 一瀬貴大，池中良徳，藤岡一俊，平久美子，中山翔太，水川葉月，八木橋美緒，有薗幸司，加藤恵介，高橋圭介，石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population (2017)
  • Author(s): Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] In situ肝灌流試験によるワルファリン抵抗性クマネズミでのワルファリン代謝能の解明 (2017)
  • Author(s): 武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] 幼児における尿中ネオニコチノイド濃度とその曝露実態の解明 (2017)
  • Author(s): 池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、遠山千春、石塚真由美
  • Organizer: 第26回環境化学討論会
• [Presentation] 高次栄養段階生物への化学物質の感受性の種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 2017年度第31回講演会
  • Int'l Joint Research / Invited
• [Presentation] UDP-glucuronosyltransferase (UGT) among Pinnipedia and other carnivores (2017)
  • Author(s): Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomiyama, Shinsuke Tanabe, and Mayumi Ishizuka
  • Organizer: the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
  • Int'l Joint Research
• [Presentation] Inveatigation of biochemical changes in cat exposed organohalogen compounds (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: the 19th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 19)
  • Int'l Joint Research
• [Presentation] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価 (2017)
  • Author(s): 水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] Studies on polycyclic aromatic hydrocarbons formation in heat-treated meat (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] 肝灌流試験、in vitro酵素活性試験による東京由来ワルファリン抵抗性クマネズミのワルファリン代謝能の解明 (2017)
  • Author(s): 武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] 幼児のネオニコチノイド系農薬の曝露評価に関する研究 (2017)
  • Author(s): 池中良徳、宮原裕一、一瀬貴大、八木橋美緒、中山翔太、水川葉月、平久美子、有薗幸司、高橋圭介、加藤恵介、遠山千春、石塚真由美
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] in vivo exposure to PCBs in cats: Analysis of metabolic capacities and effects on the thyroid hormone homeostasis (2017)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Hiroyuki Nishikawa, Misaki Maehara, Nana Takai, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: 37th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2017)
  • Int'l Joint Research
• [Presentation] エストロジェン類高感度分析法の開発と野生動物におけるスクリーニング (2017)
  • Author(s): 新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、伊藤真輝、高江洲昇、大澤夏生、綿貫豊、石塚 真由美
  • Organizer: 第23回日本野生動物医学会大会
• [Presentation] 全国規模での鳥類への鉛曝露：曝露指標として骨の利用の可能性 (2017)
  • Author(s): 石井千尋，中山翔太，池中良徳，Kataba Andrew，齊藤慶輔，渡辺有希子，槇納好岐，松川岳久，久保田章乃，横山和仁，水川葉月，平田岳史，石塚真由美
  • Organizer: 第23回日本野生動物医学会大会
• [Presentation] Heavy metal residues in some ready-to-eat meat products marketed in Egypt (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Trends of childhood blood lead levels and remedial options in Kabwe, Zambia (2017)
  • Author(s): John Yabe, Haruya Toyomaki, Shouta MM Nakayama, Yared B. Yohannes,Kaampwe Muzandu, Andrew Kataba, Kennedy Choongo, Russell Dowling, Jack Caravanos, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Quantification of Urinary Neonicotinoids in Patients of three Hospitals in Kumasi, (2017)
  • Author(s): Collins Nimako, Yoshinori Ikenaka, Osei Akoto, Mayumi Ishizuka, Nester Bortey-Sam
  • Organizer: Ghana,9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] UDP-glucuronosyltransferase (UGT) 2B genetic feature and activities in Carnivores (2017)
  • Author(s): Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomyama, Shinsuke Tanabe, and Mayumi Ishizuka,
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Novel sequencing of genes in a South African sentinal fish species (2017)
  • Author(s): Claire M Edwards, Yoshinori Ikenaka, Aksorn Saengtienchai, Mayumi Ishizuka, Johan HJ van Vuren, Richard Greenfield
  • Organizer: 9th International Toxicology Symposium in Nigeria,2017,2017,1,1
  • Int'l Joint Research / Invited
• [Presentation] Wild rat’s bio-distribution analysis for pesticide DDT from South Africa (2017)
  • Author(s): Tetsuro Ogawa, Yoshinori Ikenaka, Yared B Yohannes, Lesa Thompson, Johan van Vuren, Victor Wepener, Nico J Smit, Wynand Vlok, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] 東京由来殺鼠剤抵抗性ラットを用いた新規抵抗性獲得機序の解明 ペントースリン酸経路の亢進による殺鼠剤代謝能の活性化 (2017)
  • Author(s): 武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
  • Organizer: ,第160回日本獣医学会学術年会
• [Presentation] 鳥類医学の発展に向けた新規腎障害マーカーの探索 (2017)
  • Author(s): 石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美
  • Organizer: 日本鳥学会２０１７年度大会
• [Presentation] 鳥類におけるグルクロン酸抱合能の種差の解明と化学物質感受性の推定 (2017)
  • Author(s): 新屋惣、池中良徳、中山翔太、水川葉月、伊藤真輝、高江洲昇、齊藤 慶輔、渡邊 有希子、石塚 真由美
  • Organizer: 日本鳥学会２０１７年度大会
• [Presentation] 海鳥を介した汚染物質輸送 (2017)
  • Author(s): 庄子晶子、K. Elliott, S. Aris-Brosou、水 川葉月、中山翔太、池中良徳、石塚真由美、桑江朝比呂、渡辺謙太、綿貫豊
  • Organizer: 日本鳥学会２０１７年度大会
• [Presentation] 幼児および新生児のネオニコチノイド系農薬曝露の実態 (2017)
  • Author(s): 池中良徳
  • Organizer: 市民公開シンポジウム「化学物質の内分泌かく乱作用研究の最新動向」
  • Invited
• [Presentation] Nobel investigation of mechanism of rodenticide resistance ~ enhanced pentose phosphate pathway causes rapid metabolism of warfarin ~ (2017)
  • Author(s): Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH),
  • Int'l Joint Research
• [Presentation] Effects of Organohalogen Compounds on Serum Biochemical Profiles in Cats (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarker in birds by transcriptome analysis of kidney tissues and glycomics analysis of plasma following renal damage in chicken model. (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Drug metabolism enzymes in Carnivora species (2017)
  • Author(s): Takamitsu Kondo, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yusuke K. Kawai, Hazuki Mizukawa, Yoko Mitani, Kei Nomyama, Shinsuke Tanabe and Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
• [Presentation] “First, do no harm” ? balancing the benefits of malaria control against the toxic effects of DDT use (2017)
  • Author(s): Lesa THOMPSON, Yoshinori IKENAKA, Yared YOHANNES, Atnafu ASSEFA, Johan VAN VUREN, Victor WEPENER, Nico SMIT, Wynand VLOK, Wageh Sobhy DARWISH, Shouta NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Indoor exposure for polychlorinated biphenyls (PCBs) in domestic cats ~Pilot study of Mongolian pet cat~ (2017)
  • Author(s): Hazuki Mizukawa, Yoshinori Ikenaka, Tsend-Ayush Sainnoxoi, Kohki Takaguchi, Kei Nomiyama, Shouta M.M. Nakayama, Mayumi Ishizuka
  • Organizer: The 2nd Symposium on the Improvement of Diagnosis and Prevention of some Diseases Caused by Environmental Change
  • Int'l Joint Research / Invited
• [Presentation] Effect of DDTs on gallinacins in the avian immune system (2017)
  • Author(s): Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarkers in birds by transcriptome analysis and glycomics analysis following kidney injury in chicken model (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM)
  • Int'l Joint Research
• [Presentation] Evaluation of utility for stable lead isotope ratios to identify lead sources and verifying biological fractionation of lead isotopes in goats and chickens (2017)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Biochemical Alterations due to PCBs and PBDEs Exposures in Cats (2017)
  • Author(s): Kraisiri Khidkhan, Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Shota M. M. Nakayama, Nozomu Yokoyama, Kazuyoshi Sasaoka, Osamu Ichii, Mitsuyoshi Takiguchi, Hiroyuki Nishikawa, Keisuke Tanaka, Kohki Takiguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia (2017)
  • Author(s): Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Evaluation of Neonicotinoid insecticides exposure levels of infants and newborns (2017)
  • Author(s): Yoshinori Ikenaka
  • Organizer: Symposium at the Faculty of Health Sciences, University of Beira Interior
  • Int'l Joint Research / Invited
• [Presentation] ポリ塩化ビフェニル（PCBs）がネコの甲状腺機能に及ぼす影響 (2017)
  • Author(s): 水川葉月、高居名菜、野見山桂、高口倖暉、横山望、市居修、滝口満喜、池中良徳、中山翔太、石塚真由美
  • Organizer: 環境ホルモン学会第20回研究発表会
• [Presentation] Evaluation of indoor residual spraying DDT for mosquito control: Tissue distribution and gene expression profiling in rat tissues (2017)
  • Author(s): Emmanuel Temiotan Ogbomida, Alex Ajeh Enuneku, Yoshinori Ikenaka, Yared Beyene Yohannes, Wageh Sobhy Darwish, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 環境ホルモン学会第20回研究発表会
• [Presentation] 幼児および新生児におけるネオニコチノイド系殺虫剤の曝露実態 (2017)
  • Author(s): 池中良徳、宮原裕一、一瀬貴大、中山翔太、水川葉月、市川剛、遠山千春、石塚真由美
  • Organizer: 環境ホルモン学会第20回研究発表会
  • Invited
• [Presentation] 東京のワルファリン抵抗性ラットの抵抗性獲得機序の解明：ペントースリン酸経路の亢進を通したワルファリン代謝の活性化 Investigation of mechanism of warfarin resistance of wild rats in Tokyo ~ enhanced pentose phosphate pathway causes rapid metabolism of warfarin ~ (2017)
  • Author(s): Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 2017年度生命科学系学会合同年次大会（ConBio2017）
• [Presentation] Evaluation of the neonicotinoid insecticides exposure for infants and newborns in Japan (2017)
  • Author(s): Yoshinori Ikenaka
  • Organizer: International Conference on Environmental Health and Environmental-related Cancer Prevention 2017
  • Int'l Joint Research / Invited
• [Presentation] スーパーラットは高NADPH産生能を持つ ～東京の殺鼠剤抵抗性ラットにおける抵抗性獲得機序の解明～ (2017)
  • Author(s): 武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
  • Organizer: 第3回 北大部局間横断シンポジウム
• [Presentation] ザンビア・カブエ鉱床における鉛汚染問題とその解決に向けた取り組み-KAbwe Mine Pollution Amelioration Initiative (KAMPAI Project)- (2017)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Organizer: 第3回 北大部局間横断シンポジウム
• [Remarks] 北海道大学大学院獣医学研究院 毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] 9th International Toxicology Symposium in Nigeria
  • URL: http://aa.vetmed.hokudai.ac.jp/en/symposium-index/9th-symposium/
• [Funded Workshop] 9th International Toxicology Symposium in Nigeria (2017)