Development of Matrix Materials Mimicking Simultaneous Osteogenesis and Adipogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institute for Materials Science
• Principal Investigator: Chen Guoping 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (50357505)
• Co-Investigator(Renkei-kenkyūsha): KAWAZOE Naoki 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, 主幹研究員 (90314848)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マトリックス材料 / 生体模倣材料 / 足場材料 / 再生医療 / 幹細胞

Outline of Final Research Achievements

The extracellular matrix (ECM) is dynamically remodeled to regulate stem cell functions during tissue development. Here, we have prepared novel types of matrices that mimic the dynamic variation of ECMs by using simultaneous osteogenesis and adipogenesis of mesenchymal stem cells (MSCs). The matrices had different effects on differentiation of MSCs due to the different compositions depending on the differentiation stage. Late osteogenesis and early adipogenesis (LOEA) and late osteogenesis and late adipogenesis (LOLA) matrices promoted osteogenesis but not adipogenesis. Early osteogenesis and early adipogenesis (EOEA) matrices promoted adipogenesis but not osteogenesis. Early osteogenesis and late adipogenesis (EOLA) did not promote either osteogenic or adipogenesis. The tissue development mimicking matrices can be prepared at large scale and thus should be useful as versatile biomaterials.

Free Research Field

再生医工学