Exploration of genomic signals controlling energy metabolism and its application to lifestyle-related diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03092
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Yahagi Naoya 筑波大学, 医学医療系, 准教授 (60420246)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: エネルギー代謝 / 栄養 / ゲノム / 転写

Outline of Final Research Achievements

Energy metabolic control of an individual is performed with high accuracy referring to the nucleotide sequence of the genome. How do we respond to fasting and feeding? From this point of view, we have tried to comprehensively understand glucose and lipid metabolism. In this study, the in vivo Ad-luc analytical method and the TFEL scan method, which we have independently developed over the past few years, temporally and spatially resolve various signals controlling energy metabolism. As a result of searching for an unknown nuclear information processing mechanism responsible for energy metabolism, a part of the processing mechanism became clear, which can lead to the development of therapeutic strategies for lifestyle / obesity-related diseases in the future.

Free Research Field

代謝学、栄養学、分子生物学