2017 Fiscal Year Final Research Report
Elucidation of the usefulness of the control of fatty acid composition for the prevention of lifestyle-related disease and application to health science
| Project/Area Number |
15H03093
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 脂肪酸伸長酵素 / 生活習慣病 |
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| Outline of Final Research Achievements |
Liver-specific Elovl6 KO mice showed enhanced hepatic insulin signaling when they were fed a high-sucrose diet or were crossed with ob/ob mice. Through transcriptome and lipidomics analysis, we identified and characterized gene X and lipid Y as hepatic insulin signaling regulators. To define the role of Elovl6 in type 2 diabetes development, we assessed the effects of Elovl6 deletion in leptin receptor-deficient C57BL/KsJ db/db mice. The db/db-Elovl6 KO mice had a markedly increased β-cell mass with increased proliferation and decreased apoptosis, an adaptive increase in insulin, and improved glycemic control. Elovl6 is a fundamental factor linking dysregulated lipid metabolism to β-cell dysfunction, islet inflammation, and β-cell apoptosis in diabetes. Moreover, we analyzed the role of Elovl6 in macrophage and found the possibility that macrophage Elovl6 regulate the formation of beige fat.
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| Free Research Field |
代謝内分泌学
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