Dynamics of lipid bilayer membrane induced by external stimuli

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03708
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological physics/Chemical physics/Soft matter physics
• Research Institution: Kyoto University
• Principal Investigator: TANIGUCHI TAKASHI 京都大学, 工学研究科, 准教授 (60293669)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Ryoichi 京都大学, 大学院工学研究科, 教授 (10263401) ; MOLINA John 京都大学, 大学院工学研究科, 助教 (20727581)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ソフトマター物理 / 脂質膜 / 自発曲率 / 計算物理

Outline of Final Research Achievements

In this study, to clarify the physical mechanism behind bio-membrane functions in response to an external stimulus, we have addressed the two following questions: (1) how a chemical substance (local stimulus) induces a change in the membrane dynamics and (2) how a specific chemical concentration field (global stimulus) can induce large length- and long-time scale shape deformations. In the study of the membrane response to a local stimulus, we found that the competition between local composition fluctuations and the interaction between the lipid-composition and stimulated Glycosyl-Phosphatidyl-Inositol Anchored Receptors (GPI-AR) is the key factor to determine the formation of GPI clusters and the temporal domain of the lipids. Regarding to the membrane deformation by a global stimulus (i.e., an injection of NaOH-aq. solution), we found that the ion transport by convection and diffusion controls the membrane deformation dynamics.

Free Research Field

ソフトマター物理学