Development of New Nitrogen-based Ligands for Asymmetric Reactions with Highly Active Catalysts

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03808
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Nagoya Industrial Science Research Institute (2016-2017); Nagoya University (2015)
• Principal Investigator: NISHIYAMA HISAO 公益財団法人名古屋産業科学研究所, 研究部, 研究員 (40135421)
• Co-Investigator(Kenkyū-buntansha): 伊藤 淳一 名古屋大学, 工学研究科, 講師 (20402480)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 有機合成 / 不斉合成 / 触媒 / 有機金属化学 / 光学活性化合物

Outline of Final Research Achievements

In organic synthesis, it is important to develop new catalytic reaction providing useful optically active compounds. We have developed new nitrogen-based multidentate ligands for asymmetric catalysis. As N,C,N-type or N,N,O-type ligands, bis(oxazolinyl)phenyl or binaphthol-phenanthroline derivatives were examined to show high stereoselectivity and enantioselectivity for asymmetric conjugate silylation of substituted cyclohexadienones, conjugate addition and susequent alkylation, α－oxidation of oxindole skeleton etc., in the combination with a variety of metals. Plausible catalytic cycles including intermediate or transition state were examined by theoretical calculation to give the corresponding structures for asymmetric conjugate hydrosilylation.

Free Research Field

有機合成化学