2018 Fiscal Year Final Research Report
Development of Stereoselective Hydrofuctionalizations
| Project/Area Number |
15H03810
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka City University (2016-2018)
Kyoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 触媒 / 不斉合成 / イリジウム / C-H活性化 / ヒドロ官能基化 / 付加反応 / 立体選択性 |
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| Outline of Final Research Achievements |
We have developed following atom-economical organic transformations by using iridium catalysts, which include stereoselective addition of H-X bonds (X = C, N, O) to carbon-carbon unsaturated bonds, so-called hydrofuntionalization: (1) Stereoselective addition reactions involving C-H bond activation, (2) Asymmetric intramolecular cyclization of alkenylamides, and (3) Asymmetric intramolecular cyclization of alkenylcarboxylic acids.
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| Free Research Field |
有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
遷移金属触媒を用いた不飽和結合へのH-X結合の付加反応は，無駄となる原子のない高原子効率型反応であり，その開発は有用な有機化合物合成プロセスに必要不可欠である．本研究で開発された反応は，様々な炭素骨格やアルキルアミン，エーテル，エステル類合成の新しい手法である．さらに，不斉付加反応にも成功しており，生理活性物質や天然物など幅広い化合物の効率的な合成にも応用できる可能性を持つ．
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