Development of supercritical plasma flow field aiming at one-step synthesis of composite nanoparticles for drug delivery

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03919
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: Osaka University
• Principal Investigator: SHIGETA Masaya 大阪大学, 接合科学研究所, 准教授 (30431521)
• Co-Investigator(Kenkyū-buntansha): 田中 学 大阪大学, 接合科学研究所, 教授 (20243272)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Takayuki 九州大学, 工学研究院, 教授 (40191770)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 流体工学

Outline of Final Research Achievements

The objective of this study is to develop one-step mass-production of deliverable nanoparticles by a supercritical plasma flow controlling the nanoparticles' yield, size, and composition on the basis of fluid mechanics. An experiment system consisting of a pressure-proof chamber to produce and sustain supercritical fluid and an electric power supplier capable of generating plasma under a high pressure was designed and constructed. The correlations between the flow characteristics of supercritical plasma and the material characteristics of products were clarified by experimental and theoretical approaches. Experimental methods to measure the plasma's characteristics and mathematical models to analyze the mechanisms were developed as well.

Free Research Field

流体工学