Measurement and analysis of temperature characteristics and thermal physics of blood cell, blood flow and blood vessel using microfluidic platform

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H03931
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: Kyoto University
• Principal Investigator: Kazuya Tatsumi 京都大学, 工学研究科, 准教授 (90372854)
• Co-Investigator(Renkei-kenkyūsha): NAKABE Kazuyoshi 京都大学, 大学院工学研究科, 教授 (80164268)
• Research Collaborator: HIRAKATA Hideo 京都市立病院, 研究員 (70271509) ; SUGITA Naoko 京都大学, 大学院医学研究科, 助教 (20750532) ; KURIYAMA Reiko 京都大学, 大学院工学研究科, 助教 (70781780)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血栓 / 熱物性 / マイクロ流体工学 / 反応定数 / 静脈血栓 / フィブリン / トロンビン / 凝固時間

Outline of Final Research Achievements

Point of origin and the formation process of the thrombus, thrombus formation time, and the reaction constant of fibrin reaction was measured using microfluidic device, micro-capillary, and cuvette for human blood to evaluate the effects of flow and temperature on vinous thrombus formation. We showed that in the case of low flow rate observed in vein, the fibrin fibers grow from the platelets attached to the channel wall from which the thrombus starts to form. The pattern of the fibrin fibers showed a correlation with the mass concentration pattern diffused and convected from the platelet, the results from which we showed that the flow and concentration of the coagulation factors affects the thrombus formation. Further, the relationship between the temperature and the thrombus formation time and the fibrin concentration showed that the thrombus formation time increases as the temperature increase or decrease from the range of 37-40C due to the decrease of the reaction coefficient.

Free Research Field

伝熱工学