Phsyiology of axons and axon terminals.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04261
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Doshisha University
• Principal Investigator: Sakaba Takeshi 同志社大学, 脳科学研究科, 教授 (80609511)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI Shinya 京都大学, 産官学連携本部, 特定准教授 (00378530) ; MIDORIKAWA Mitsuharu 東京女子医科大学, 医学部, 准講師 (60632643)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: シナプス / 軸索

Outline of Final Research Achievements

In this study program, we have directly patch-clamped from axons and axon terminals at mammalian CNS neurons to elucidate their physiological properties. In addition, we employed imaging techniques such as TIRF (total internal reflection fluorescent micsroscopy), to reveal the underlying mechanisms. In axons, action potentials are propagated reliably in some neuron types whereas they are attenuated in other types. In presynaptic terminals, transmitter release kinetics differ considerably among synapse types, which may be mediated by different coupling distance between Ca channels and synaptic vesicles. Moreover, second messengers may modulate the coupling distance, which may mediate short- and long-term presynaptic plasticity.

Free Research Field

神経科学