2017 Fiscal Year Final Research Report
Molecular and cellular mechanisms of active zone structure and function by the CAST/ELKS protein family
| Project/Area Number |
15H04272
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 神経科学 / 神経伝達物質・受容体 / アクティブゾーン |
|---|
| Outline of Final Research Achievements |
In this project, we have attempted to uncover physiological roles of the presynaptic active zone proteins CAST and ELKS in basic neurotransmitter release, synaptic plasticity, and neural circuit formation. Then, we have demonstrated that CAST is involved in release probability of synaptic vesicle and its recycling with Rab6, and that SAD kinase-mediated phosphorylation of CAST controls active zone vesicle recycling for synaptic depression. CAST and ELKS ablation studies have also revealed that CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus, the size and ribbon synapse formation in the retina, and neural circuit formation in the cerebellum.
These results suggest that the CAST/ELKS protein control not only basic neurotransmitter release but also synaptic reorganization in the brain.
|
| Free Research Field |
神経科学
|
