2018 Fiscal Year Final Research Report
Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology
| Project/Area Number |
15H04275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University (2018)
Kyoto University (2015-2017) |
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Principal Investigator |
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| Research Collaborator |
MACPHERSON Tom
MORITA Makiko
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 大脳基底核 / 報酬学習 / 忌避学習 / ドーパミン / 神経回路 / 精神疾患 / 海馬 |
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| Outline of Final Research Achievements |
We have analyzed the basal ganglia network mechanisms in cognitive learning. We found the pathway-specific intracellular signaling in aversive learning. Furthermore, we revealed the involvement of the indirect pathways and dopamine D2L receptors in flexibility of reward learning. Next, we examined reward place learning of mutant DISC1 transgenic mice as a mouse model of mental disorders. We have found the impairment in reward place learning of mutant DISC1 transgenic mice with social isolation stress. Reward-related neural activity was disappeared in hippocampal CA1 place cells of mutant DISC1 mice.
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| Free Research Field |
神経科学、精神医学
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| Academic Significance and Societal Importance of the Research Achievements |
多くの精神神経疾患には認知行動障害が基礎症状として存在するが、その神経基盤は解明されていない。本研究では、認知学習における大脳基底核神経回路機構を解析し、報酬・忌避学習の神経基盤を明らかにした。また、精神疾患モデルマウスの報酬学習異常とその神経基盤を見出した。これらの研究成果は、精神神経疾患の病態を神経回路という新しい視点から解明するもので、新しい治療法開発につながることが期待できる。
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