The mechanism for the positioning of cell nucleus at the cell center

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04372
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: National Institute of Genetics
• Principal Investigator: Kimura Akatsuki 国立遺伝学研究所, 構造遺伝学研究センター, 教授 (10365447)
• Co-Investigator(Renkei-kenkyūsha): GODA Makoto 浜松医科大学, 光尖端医学教育研究センター, 研究技術職員 (70442960)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞核 / 線虫 / 微小管 / 力

Outline of Final Research Achievements

In many cell types, the cell nucleus is positioned at the center of the cell. The mechanism to position the nucleus at the cell center is still under debate. In this research project, we obtained results to support ‘cytoplasmic pulling model’, in which the nucleus moves toward the cell center by the pulling force produced throughout the cytoplasm. Moreover, we have succeeded to measure the forces required to move the nucleus in a living cell. These achievements advanced the mechanism for the positioning of cell nucleus at the cell center.

Free Research Field

細胞生物学