Study on structure and function of the processing enzyme for pre-tRNA and its application

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04487
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Kyushu University
• Principal Investigator: Kimura Makoto 九州大学, 農学研究院, 学術特任教員 (10204992)
• Co-Investigator(Kenkyū-buntansha): 中島 崇 九州大学, 農学研究院, 助教 (20380553) ; 角田 佳充 九州大学, (連合)農学研究科(研究院), 教授 (00314360)
• Co-Investigator(Renkei-kenkyūsha): MAYANAGI Kota 九州大学, 生体防御医学研究所, 助教 (50418571)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リボヌクレアーゼP / アーキア / tRNAプロセシング酵素

Outline of Final Research Achievements

Ribonuclease P (RNase P) is a ribonucleoprotein that cleaves off 5´ leader sequences from tRNA precursors in all living cells and consists of a catalytic RNA and protein cofactors. In this study, I performed the structure and functional study of RNase P from the hyperthermophilic archaeon Pyrococcus horioshii and also examined potentiality of the RNase P proteins for bioanalytical application where precise hybridization of nucleic acids is needed.

Free Research Field

生物化学