2017 Fiscal Year Final Research Report
Preventive effects on metabolic syndrome through adipose tissue browning induced by marine carotenoids
| Project/Area Number |
15H04545
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡松 優子 北海道大学, 獣医学研究院, 講師 (90527178)
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| Research Collaborator |
KATSUKI Ami
OHUCHI Yuka
TYA Daisuke
TATEYAMA Riho
AKITA Tomoki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 海洋性カロテノイド / 脂肪組織 / 褐色化 / ミトコンドリア因子 / UCP1 / フコキサンチン / メタボリックシンドローム予防 / プロジェニター細胞 |
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| Outline of Final Research Achievements |
Fucoxanthin contained in brown seaweeds suppressed weight gain of white adipose tissue (WAT) through induction of mitochondrion factors including uncoupling protein 1 (UCP1) in adipose tissues. In diet-induce obese mice fed fucoxanthin, fatty acid oxidation was promoted. Induction of the brown adipocyte-like phenotype was also observed in C3H10T1/2 adipocytes treated with fucoxanthin metabolites. PGC-1alpha is suggested to be a critical factor to induce browning in white adipocytes by fucoxanthin. On the other hand, the number of progenitor cells to differentiate into beige adipocytes was demonstrated to decrease with aging.
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| Free Research Field |
水圏生命科学
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