2017 Fiscal Year Final Research Report
Organic synthesis using reactive salt intermediate
| Project/Area Number |
15H04632
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
有澤 光弘 大阪大学, 薬学研究科, 准教授 (40312962)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 塩化学種 / 求核置換反応 / フッ素化合物 / ピリジニウム塩 / in situ protection法 / one-pot reaction / ホスホニウム塩 |
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| Outline of Final Research Achievements |
As an organic synthesis using pyridinium salt intermediates efficient synthesis of ether compounds from acetals, N-CF3SCH2-indol derivatives, trifluoromethylthiomethyl ethers and fluoromethylethers from MOM-ethers has been developed.
As an organic synthesis using phosphonium salt intermediates new in situ protection methodology, selective transformations of ketones, beta,beta-disubstituted enones, and alpha,beta-unsaturated ketones in the presence of beta-monosubstituted enone, has been developed. One-pot six steps procedure for cyclic ether compounds from the compounds having eone and alpha,beta-unsaturated ketone in the same molecule has also been developed.
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| Free Research Field |
精密合成化学
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