2017 Fiscal Year Final Research Report
A novel rescue factor for Alzheimer's disease
| Project/Area Number |
15H04689
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
羽生 春夫 東京医科大学, 医学部, 主任教授 (10228520)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | CLSP / humanin / アルツハイマー病 |
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| Outline of Final Research Achievements |
The mechanism underlying the Alzheimer’s disease (AD) pathogenesis and the detailed regulation of the rescue activity of calmodulin-like skin protein (CLSP)have been addressed. First, multiple CLSP-inhibitors have been identified and their ways of CLSP inhibition have been investigated in detail. The mechanism underlying the neuronal cell death by an uncoordinated-5C variant, an AD risk protein, has been elucidated. Second, it has been shown using CLSP transgenic mice that the overexpression of CLSP antagonizes the synaptic loss and memory impairment in AD model mice. Finally, the concentrations of CLSP in the human cerebrospinal fluids have been shown to be unaffected by the presence of AD.
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| Free Research Field |
薬理学
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