2017 Fiscal Year Final Research Report
Regulation of signal transduction by TRIM family proteins
| Project/Area Number |
15H04690
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Hidehisa 横浜市立大学, 大学院医学研究科, 教授 (20399819)
WATANABE Masashi 北海道大学, 医学研究院, 助教 (10632424)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ユビキチン / シグナル伝達 / タンパク質分解 / タンパク質修飾 / 転写 |
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| Outline of Final Research Achievements |
Our previous studies have shown the importance of TRIM family ubiquitin ligase in intracellular signal transduction. Especially, we showed that TRIM family ubiquitin ligase regulates signal transduction involved in cell proliferation and differentiation. Therefore, in this application, we identified and analyzed TRIM family ubiquitin ligases which regulates the ubiquitination in various intracellular signalling pathways. Furthermore, we identified and analyzed candidate genes regulating metabolism and immune signal by comprehensive knockdown of TRIM family genes using their siRNA library.
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| Free Research Field |
医化学
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