2017 Fiscal Year Final Research Report
Analysis on the involvement of the new transcriptional elongation regulator Med26 in mixed acute leukemia
| Project/Area Number |
15H04701
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University (2017)
Hokkaido University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 遺伝子発現制御 / 転写 / 転写伸長 |
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| Outline of Final Research Achievements |
In this study,we addressed the mechanisms how Med26 and SEC collaborate to release the paused Pol II and clarified the mechanism of promoting tumor growth. Furthermore, we clarified how Med26 regulates the transcriptional expression of the distinct genes by recruiting two distinct transcription elongation complexes SEC and LEC.
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| Free Research Field |
生化学
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