Subclassification of lung cancers without driver mutations

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04714
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Ishikawa Yuichi 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺癌 / ドライバー変異

Outline of Final Research Achievements

Lung cancers without driver mutations (EGFR, KRAS, ALK etc.) are thought to relate with exogenous carcinogens such as smoking. In this study, we focused on exposure to cigarette smoke and asbestos and comprehensively investigated mRNA and miRNA expression. By comparing cumulative smoking, asbestos burden with miRNA expression, we successfully identified specific miRNA to asbestos exposure. Although we attempted to perform integrated analysis using mRNA and miRNA expression, clusters drawn from mRNA and miRNA were not identical. Also, we examined PD-L1 expression in adenocarcinoma and small cell carcinoma and found that PD-L1 expression in small cell carcinoma was unexpectedly a marker for good prognosis.

Free Research Field

腫瘍病理学