2017 Fiscal Year Final Research Report
Characterization of SPP involved in pathogenesis of HCV
| Project/Area Number |
15H04736
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Toru 大阪大学, 微生物病研究所, 准教授 (80628595)
FUKUHARA Takasuke 大阪大学, 微生物病研究所, 准教授 (70598739)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | SPP / HCV |
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| Outline of Final Research Achievements |
We have previously reported that the maturation of core protein of hepatitis C virus (HCV) by the cleavage with signal peptide peptidase (SPP) is essential for propagation of HCV. In this study, we examined the inhibitory activity of inhibitors for γ-secretase, another intramembrane cleaving protease, to SPP and revealed that interaction of Val223 in SPP with dibenzoazepine structure in the γ-secretase inhibitors is critical for inhibition of SPP. Treatment with SPP suppressed maturation of HCV core proteins of all genotypes of HCV and did not induce emergence of drug-resistant viruses. These results suggest that SPP is an ideal target for the development of therapeutics against chronic hepatitis C.
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| Free Research Field |
ウイルス学
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