2017 Fiscal Year Final Research Report
The mechanisms of chronic inflammation by Gateway Reflex and inflammation amplifier
Project/Area Number |
15H04741
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | 炎症アンプ / ゲートウェイ反射 |
Outline of Final Research Achievements |
A correlation between pain intensity and the pathogenesis of inflammation is poorly established and still unclear. In this application, we elucidated that a pain evoked relapse of multiple sclerosis. Moreover, we revealed that brain micro-inflammation around specific vessels caused by chronic-stress could be switch to activate new neural pathway to regulate organ homeostasis. In addition, we identified positive-regulator of inflammation amplifier by genome wide screening. Among them, we focused on BCR and Rbm10, and clarified the mechanisms of inflammation amplifier.
|
Free Research Field |
神経免疫学
|