Development of new preventive methods for food allergy using of the analysis on epigenetics on lymphocytes and intestinal flora microbiome

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04783
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kanazawa University
• Principal Investigator: NAKAMURA Hiroyuki 金沢大学, 医学系, 教授 (30231476)
• Co-Investigator(Kenkyū-buntansha): 辻口 博聖 金沢大学, 医学系, 特任助教 (00723090) ; 神林 康弘 金沢大学, 医学系, 講師 (20345630) ; 福冨 友馬 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110) ; 八田 耕太郎 順天堂大学, 医学部, 教授 (90337915)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 食物アレルギー / アレルゲン / エピジェネティクス / 腸内細菌 / Tリンパ球 / テイラーメイド予防法 / DNAメチル化 / 16S rRNA遺伝子

Outline of Final Research Achievements

To develop new biomarker for food allergy, we have performed analysis of trascriptome and epigenome of T cell and the strain of intestinal flora and metagenome in infants aged1-3 with fool allergy and its control. In results, more significantly frequent methylation of T cell and less richness and diversity of the strain were seen in the food allergic infants. These results suggest that less richness and diversity of the strain produce the methylation of T cell, subsequently leading to the development of food allergy. The richness and diversity of the strain may be efficient biomarkers for food allergy.

Free Research Field

公衆衛生学、予防医学