Molecular epidemiology study of inflammation-associated disease development on the basis of long-term follow-up of atomic-bomb survivors

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04791
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAYASHI Tomonori 公益財団法人放射線影響研究所, 分子生物科学部, 副部長 (70333549)
• Co-Investigator(Kenkyū-buntansha): 徳永 勝士 東京大学, 大学院医学系研究科(医学部), 教授 (40163977) ; 安波 道郎 地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), 疾患ゲノムセンター, 部長 (80244127)
• Co-Investigator(Renkei-kenkyūsha): NAKACHI Kei 公益財団法人 放射線影響研究所, 分子生物科学部, 顧問 (00142117) ; Cologne John 公益財団法人 放射線影響研究所, 統計部, 主任研究員 (50344411) ; YOSHIDA Kengo 公益財団法人 放射線影響研究所, 分子生物科学部, 研究員 (70443596)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ゲノム / 放射線 / 炎症 / 遺伝子多型

Outline of Final Research Achievements

We observed a significant interaction between certain genotype of CHEK2 gene, which is related to DNA damage response, and radiation exposure dose in the increase risk of proximal colon cancer in atomic-bomb survivors. Among 160,000 SNPs, the number of SNPs with P values less than 10-3 related to breast cancer, liver cancer, and colon cancer risks in atomic-bomb survivors were 10, 8, and 12 SNPs, respectively, but there were no SNPs with P values less than 10-6.
As a result of measurement of the membrane type IL-6R (mIL-6R) levels of healthy subjects by IL6R genotypes, the mIL-6R levels of the CD4+ helper T cells of the other genotype group was higher than that of the IL6R-A/A group, and the intracellular O2.- levels were significantly higher.

Free Research Field

免疫学　分子疫学