2017 Fiscal Year Final Research Report
Translational research of therapeutic vaccine to improve the quality of anti-hypertensive therapy
| Project/Area Number |
15H04803
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679)
苅尾 七臣 自治医科大学, 医学部, 教授 (60285773)
新保 昌久 自治医科大学, 医学部, 教授 (70406049)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ワクチン |
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| Outline of Final Research Achievements |
Vaccines are commonly used as preventive methods, primarily against infectious diseases. The goal of our study is to develop the therapeutic vaccine for hypertension. Increasing the effectiveness of drug adherence interventions in the clinical setting may have a large impact on the health of the population. We and others recently reported that an angiotensin II (AngII) vaccine for hypertension successfully attenuated elevated blood pressures in an animal model without any immunogenic side effects. In this system, an immunogenic molecule (i.e., KLH) with adjuvants provides an antigen that supports the activation of helper T cells. In addition, pretreatment with the AngII vaccine exerts neuroprotective effects in a cerebral ischemia model and cardioprotective effects in a myocardial infarction model. We developed the DNA and peptide vaccine with GMP grade and evaluated the efficiency of these vaccines in animal model (SHR). We have almost set up the preparation of clinical trials.
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| Free Research Field |
高血圧
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