2017 Fiscal Year Final Research Report
Regulatory mechanism of mitochondrial iron contents by mitoMEET in cardiac remodeling
| Project/Area Number |
15H04815
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University (2016-2017)
Hokkaido University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
絹川 真太郎 北海道大学, 医学研究院, 講師 (60399871)
松島 将士 九州大学, 大学病院, 助教 (80552869)
井手 友美 九州大学, 医学研究院, 准教授 (90380625)
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| Research Collaborator |
FURIHATA Takaaki
IKEDA Masataka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 心不全 / 心筋リモデリング / ミトコンドリア / 鉄代謝 |
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| Outline of Final Research Achievements |
We generated mitoNEET knockout mice and investigated regulatory mechanisms of mitochondrial iron by mitoNEET. Mitochondrial iron contents and ferritin levels in the heart were increased in mitoNEET-KO mice compared with wild-type mice.
We detected adenine nucleotide translocator (ANT) as a novel protein binding to mitoNEET. Administration of cyclosproin A, an inhibitor of mitochondrial permeability transition pore opening, decreased mitochondrial iron contents, indicating that mitoNEET and ANT coordinately regulate mitochondrial iron contents.
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| Free Research Field |
循環器内科学
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