Trial to develop a personalized adoptive immunotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15H04831
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hiroshima University
• Principal Investigator: Hattori Noboru 広島大学, 医歯薬保健学研究科(医), 教授 (00283169)
• Co-Investigator(Kenkyū-buntansha): 河本 宏 京都大学, ウイルス・再生医科学研究所, 教授 (00343228)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 養子免疫療法 / 癌特異的変異抗原 / 腫瘍浸潤性Tリンパ球

Outline of Final Research Achievements

To develop a personalized immunotherapy of lung cancer, we searched for a new tumor antigen specific to tumor cells. We collected peripheral blood mononuclear cells and malignant pleural effusion, and established primary cultures of cancer cells derived from pleural effusion. Whole-exome sequencing of mononuclear cells and cancer cells derived from the same patient identified 389 indels and 6616 SNPs. We found several candidates for new tumor antigens using the computational algorithm to identify HLA-binding peptides.

Free Research Field

呼吸器内科学