2017 Fiscal Year Final Research Report
Evaluation of bone tissue as a regulatory center of hematopoiesis
| Project/Area Number |
15H04856
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
|
|---|
| Research Institution | Kobe University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | bone metabolism |
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| Outline of Final Research Achievements |
We evaluated the roles of VDR and FGF23 which are critical for homeostasis of calcium and phosphate, respectively. As an example of the deviation of inter-organ communication between bone marrow and bone, we could establish a myelofibrosis model in which VDR played a central role. Even a murine myelofibrosis induced by a gene mutation which is identical to the one in human myelofibrosis could be rescued by targeting the VDR signal. We also found that FGF23 produced from hematopoietic cells facilitated the mobilization of hematopoietic progenitor cells from bone marrow to circulation.
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| Free Research Field |
Hematology
|
