2017 Fiscal Year Final Research Report
Roles of functionally disrupted niches on hematological malignancy
| Project/Area Number |
15H04859
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 造血幹細胞 / 白血病幹細胞 / 間葉系幹細胞 / 造血微小環境 |
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| Outline of Final Research Achievements |
This study report that selected microenvironment exists and highlights the possibility of heterogeneity among mesenchymal niche cells. Recently, cellular heterogeneity within a tumor has been highlighted and among aggressively proliferating tumor cells, a small fraction is found in quiescent status, causing refractoriness to anti-cancer therapy and relapsed diseases. Even in cancer cells that appear to proliferate in an unlimited manner, environmental cues are believed to control their cell cycle status, quiescence or proliferation. Therefore, “decision” whether symmetric or asymmetric division is essential for leukemia to survive. The anatomical and functional interactions between hematopoietic cells or leukemia and their microenvironments are essential to efficiently control normal and pathological hematopoiesis. This study suggests that identification of the niches may add new concept as “anti-cancer niche” to cancer therapy.
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| Free Research Field |
血液内科学
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